Abstract
This double-blind parallel groups study investigated the effects of 7.5 mg midazolam on transient insomnia caused by eastward and westward multiple time zone flights. Three groups of six subjects each were treated with either midazolam or placebo during the first four post-flight nights in both directions. Sleep-wake behavior was monitored throughout the study by actigraphic recordings from the wrist of the non-dominant hand in 1 min bins and by morning questionnaires. The results showed that midazolam significantly lengthened sleep and increased the percentages of bins defined as sleep after the eastward flight. These results are discussed in view of recent findings that short-acting benzodiazepines induced phase shifts in mammalian circadian rhythms.
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Arendt J, Marks V (1982) Physiological changes underlying jet lag. Br Med J 284:144–146
Arendt J, Aldhous M, English J, Marke V, Arendt JH (1978) Some effects of jet-lag and their alleviation by melatonin. Ergonomics, 30:1379–1393
Aschoff J, Hoffman K, Pohl H, Wever R (1975) Reentrainment of circadian rhythms after phase-shifts of the zeitgeber. Chronobiologia 2:23–78
Desir D, van Cauter E, Fox VS, Martino E, Jadot C, Spire J, Noel P, Refetoff S, Copinschi G, Goldstein J (1981) Effects of “jet lag” on hormonal patterns. I. Procedures, variations in total plasma proteins and disruption of adrenocorticotropin-cortisol periodicity. J Clin Endocrinol Metab 52:628–641
Greenblatt DJ, Abernethy DR, Locnisker A, Harmatz JS, Limjuco PA, Shader RI (1984) Effect of age, gender and obesity on midazolam kinetics. Anesthesiol 61:27–35
Monk TH, Moline ML, Graeber CR (1988) Inducing jet lag in the laboratory patterns of adjustment to an acute shift in routine. Aviat Space Environ Med 59:703–710
Moses JM, Lubin A, Naitoh P, Johnson LC (1974) Subjective evaluation of the effects of sleep loss: the NHRC Mood Scales (Tech. Rep. No. 74–75) Naval Health Research Center, San Diego, California
Nicholson AN, Pascoe PA, Spencer MB, Stone BM, Roehrs T, Roth T (1986) Sleep after transmeridian flights. Lancet II:1205–1208
Redmond DP, Hegge FW (1985) Observations on the design and specifications of a wrist-worn human activity monitoring system. Behav Res Methods Instr Corp 17:659–669
Sadeh A, Alster, J, Urbach D, Lavie P (1989) Actigraphically based automatic bedtime sleep-wake scoring: validity and clinical applications. J Ambul Monit 2:209–216
Seidel WF et al. (1987) Jet lag after eastward and westward flights. Sleep Res 16:639
Turek FW, Losee-Olson S (1986) A benzodiazepine used in the treatment of insomnia phase shift: the mammalian circadian clock. Nature 321:167–168
Van Reeth O, Turek FW (1987) Adaptation of circadian rhythmicity to a shift in the light-dark cycle can be accelerated by a benzodiazepine. Am J Physiol 253; R201-R207
Van Reeth O, Vanderhaeghen JJ, Turek FW (1988) A benzodiazepine antagonist Ro 15–1788, can block the phase shifting effects of triazolam on the mammalian circadian clock. Brain Res 444:333–339
Wee EFB, Turek FW (1989) Midazolam, a short-acting benzodiazepine, resets the circadian clock of the hamster. Pharmacol Biochem Behav 32:901–906
Winget CM, De Roshia CW, Markley CL, Hulley DC (1984) A review of human physiological and performance changes associated with desynchronosis of biological rhythms. Aviat Space Environ Med 55:1088–1096
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Lavie, P. Effects of midazolam on sleep disturbances associated with westward and eastward flights: Evidence for directional effects. Psychopharmacology 101, 250–254 (1990). https://doi.org/10.1007/BF02244135
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DOI: https://doi.org/10.1007/BF02244135