Immune and genetic correlates of vaccine protection against mucosal infection by SIV in monkeys
NL Letvin, SS Rao, DC Montefiori… - Science translational …, 2011 - science.org
The RV144 vaccine trial in Thailand demonstrated that an HIV vaccine could prevent
infection in humans and highlights the importance of understanding protective immunity …
infection in humans and highlights the importance of understanding protective immunity …
[HTML][HTML] Anti-retroviral therapy increases the prevalence of dyslipidemia in South African HIV-infected patients
Purpose Data on the prevalence of dyslipidaemia and associated risk factors in HIV-infected
patients from sub-Saharan Africa is sparse. We performed a cross-sectional analysis in a …
patients from sub-Saharan Africa is sparse. We performed a cross-sectional analysis in a …
Population genetics inference for longitudinally-sampled mutants under strong selection
M Lacerda, C Seoighe - Genetics, 2014 - academic.oup.com
Longitudinal allele frequency data are becoming increasingly prevalent. Such samples
permit statistical inference of the population genetics parameters that influence the fate of …
permit statistical inference of the population genetics parameters that influence the fate of …
Small pelagic fish responses to fine-scale oceanographic conditions: implications for the endangered African penguin
AM McInnes, PG Ryan, M Lacerda… - Marine Ecology …, 2017 - int-res.com
Small pelagic fish play a significant role in regulating the foraging activities and population
trends of marine top predators in upwelling ecosystems, yet there is little information on …
trends of marine top predators in upwelling ecosystems, yet there is little information on …
High prevalence of cisplatin-induced ototoxicity in Cape Town, South Africa
H Whitehorn, M Sibanda, M Lacerda… - South African Medical …, 2014 - ajol.info
Background. Cisplatin is administered as the first-line treatment of soft-tissue cancers. It has
a reported cure rate of up to 85%, but is associated with a high incidence of ototoxicity …
a reported cure rate of up to 85%, but is associated with a high incidence of ototoxicity …
[HTML][HTML] The challenge of mapping the human connectome based on diffusion tractography
Tractography based on non-invasive diffusion imaging is central to the study of human brain
connectivity. To date, the approach has not been systematically validated in ground truth …
connectivity. To date, the approach has not been systematically validated in ground truth …
Effects of CYP2B6 and CYP1A2 Genetic Variation on Nevirapine Plasma Concentration and Pharmacodynamics as Measured by CD4 Cell Count in Zimbabwean …
D Mhandire, M Lacerda, S Castel… - Omics: a journal of …, 2015 - liebertpub.com
The extremely high prevalence of HIV/AIDS in sub-Saharan Africa and limitations of current
antiretroviral medicines demand new tools to optimize therapy such as pharmacogenomics …
antiretroviral medicines demand new tools to optimize therapy such as pharmacogenomics …
Unravelling the interaction between the DRD2 and DRD4 genes, personality traits and concussion risk
S Abrahams, S McFie, M Lacerda… - BMJ open sport & …, 2019 - bmjopensem.bmj.com
Background Concussion occurs when biomechanical forces transmitted to the head result in
neurological deficits. Personality may affect the balance between safe and dangerous play …
neurological deficits. Personality may affect the balance between safe and dangerous play …
Sequential regression multiple imputation for incomplete multivariate data using Markov chain Monte Carlo
M Lacerda, C Ardington, M Leibbrandt - 2007 - opensaldru.uct.ac.za
This paper discusses the theoretical background to handling missing data in a multivariate
context. Earlier methods for dealing with item non-response are reviewed, followed by an …
context. Earlier methods for dealing with item non-response are reviewed, followed by an …
Replication capacity of viruses from acute infection drives HIV-1 disease progression
P Selhorst, C Combrinck, N Ndabambi… - Journal of …, 2017 - Am Soc Microbiol
The viral genotype has been shown to play an important role in HIV pathogenesis following
transmission. However, the viral phenotypic properties that contribute to disease …
transmission. However, the viral phenotypic properties that contribute to disease …