▪ Abstract Topoisomerases are enzymes that use DNA strand scission, manipulation, and
rejoining activities to directly modulate DNA topology. These actions provide a powerful …

The HORMA domain is a multifunctional protein–protein interaction module found in diverse
eukaryotic signaling pathways including the spindle assembly checkpoint, numerous DNA …

We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and
angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD) …

The specialized two-stage meiotic cell division program halves a cell's chromosome
complement in preparation for sexual reproduction. This reduction in ploidy requires that in …

The multifunctional nucleocapsid (N) protein in SARS-CoV-2 binds the~ 30 kb viral RNA
genome to aid its packaging into the 80–90 nm membrane-enveloped virion. The N protein …

Microsatellite repeat expansions in DNA produce pathogenic RNA species that cause
dominantly inherited diseases such as myotonic dystrophy type 1 and 2 (DM1/2) …

The COVID‐2019 pandemic is the most severe acute public health threat of the twenty‐first
century. To properly address this crisis with both robust testing and novel treatments, we …

The mechanical stratigraphy of the Upper Cretaceous Austin Chalk is established from study
of fracture intensity along its outcrop trend from Dallas to San Antonio and westward to …

Self versus non-self discrimination is a key element of innate and adaptive immunity across
life. In bacteria, CRISPR-Cas and restriction-modification systems recognize non-self nucleic …

Enhancers act to regulate cell-type-specific gene expression by facilitating the transcription
of target genes. In mammalian cells, active or primed enhancers are commonly marked by …