RNA interference (RNAi) has recently emerged as a specific and efficient method to silence
gene expression in mammalian cells either by transfection of short interfering RNAs …

Most patients with pancreatic ductal adenocarcinoma (PDAC) are diagnosed with advanced
disease and survive less than 12 months. PDAC has been linked with obesity and glucose …

Lamellipodial protrusion is regulated by Ena/VASP proteins. We identified Lamellipodin
(Lpd) as an Ena/VASP binding protein. Both proteins colocalize at the tips of lamellipodia …

Extension of neurites from a cell body is essential to form a functional nervous system;
however, the mechanisms underlying neuritogenesis are poorly understood. Ena/VASP …

Abstract Author Summary Background. Autophagy is a catabolic pathway that permits cells
to recycle intracellular macromolecules, and its inhibition reduces pancreatic cancer growth …

While there have been rapid advances in developing new and more targeted drugs to treat
cancer, much less progress has been made in individualizing dosing. Even though the …

Clinically relevant subtypes exist for pancreatic ductal adenocarcinoma (PDAC), but
molecular characterization is not yet standard in clinical care. We implemented a biopsy …

▪ Abstract Over the past four years RNA interference (RNAi) has exploded onto the research
scene as a new approach to manipulate gene expression in mammalian systems. More …

Mammalian cortical development involves neuronal migration and neuritogenesis; this latter
process forms the structural precursors to axons and dendrites. Elucidating the pathways …

Prognostically relevant RNA expression states exist in pancreatic ductal adenocarcinoma
(PDAC), but our understanding of their drivers, stability, and relationship to therapeutic …