Evidence is strengthening for the morphological evaluation of tumor infiltrating lymphocytes
(TILs) in breast cancer. Herein, the concepts for TILs assessment are laid out by pathologists …

Vegetation phenology is highly sensitive to climate change. Phenology also controls many
feedbacks of vegetation to the climate system by influencing the seasonality of albedo …

Microorganisms are integral to the soil phosphorus (P) cycle and as such play an important
role in mediating the availability of P to plants. Understanding the microbial contribution to …

The chromosome 9p21 amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD)
locus contains one of the last major unidentified autosomal-dominant genes underlying …

All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

Metastasis is a multistep process during which cancer cells disseminate from the site of
primary tumors and establish secondary tumors in distant organs. In a search for key …

Mesenchymal stem cells have been recently described to localize to breast carcinomas,
where they integrate into the tumour-associated stroma. However, the involvement of …

Fibroblasts often constitute the majority of the stromal cells within a breast carcinoma, yet the
functional contributions of these cells to tumorigenesis are poorly understood. Using a …

Frontotemporal dementia (FTD) is the second most common cause of dementia in people
under the age of 65 years. A large proportion of FTD patients (35–50%) have a family history …

We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …