The cost-effectiveness and efficacy of athlete profiling and injury prevention programs is influenced by procedural specificity, philosophy of athlete development within the sporting body and the dynamics within the multidisciplinary team (MDT). This article reports on the implementation of a multidisciplinary approach to injury reduction and performance development in an international netball squad. Problems with player compliance, training anxiety and injury rates sparked a decision to seek an alternative training approach. A reactive sports medicine system, poor player self-responsibility and inadequate player understanding of the anatomy and biomechanics of sound training, inadequate screening procedures and perceived conflict between sports science and sports medicine personnel were identified as causative factors. A new program was designed where common objectives were identified, and individual roles delineated. A functional profiling session was performed as a team activity and comprised player self-evaluation and netball specific movement analysis. Mechanisms of injury, training anxieties and modification of the overall program to ensure continued progression rather than a false plateau were illustrated through this process. From the above findings a strategy was outlined and comprised a foundation programme, a transitional phase, specific prophylactic programs, and sport specific sessions. A consistent approach was formulated across all disciplines in order to maximise transference of the new training program (TP). Training compliance was increased and interdisciplinary conflict prevented when dealing with different levels of training tolerance. Rate of injury in all vulnerable areas was markedly reduced. No training or overuse related injuries were sustained. Addressing fundamental functional problems and working openly and cooperatively towards a common goal, the members of the MDT were able to prevent injury, make significant gains in physiological performance and improve players' confidence and commitment to training over the defined period.