Chest
Original Research: Resectional Lung SurgeryEvaluation of Expiratory Volume, Diffusion Capacity, and Exercise Tolerance Following Major Lung Resection: A Prospective Follow-up Analysis
Section snippets
Materials and Methods
Two hundred fifty-three patients were submitted to major lung resection for non-small cell lung cancer at our unit from June 2003 through December 2005 and were prospectively enrolled in this study. The study was approved by the local Institutional Review Board of the hospital, and all patients gave informed consent to participate in the study. Postoperative 30-day or in-hospital mortality was 4% (10 patients). Patients were evaluated using pulmonary function testing (PFT) and symptom-limited
Results
Table 1shows the values of the residual FEV1%, Dlco%, and Vo2peak with respect to preoperative values at different postoperative evaluation times.
In particular, 1 month after lobectomy FEV1%, Dlco%, and Vo2peak values were 79.5%, 81.5%, and 96% of preoperative values, respectively, and recovered up to 84%, 88.5%, and 97% after 3 months, respectively. One month after pneumonectomy, FEV1%, Dlco%, and Vo2peak values were 65%, 75%, and 87% of preoperative values, respectively, and were 66%, 80% and
Discussion
The objectives of the present study were to evaluate the changes of pulmonary function and exercise tolerance after major lung resection in patients with lung cancer, and to assess the factors associated with postoperative exercise capacity at repeated postoperative evaluation times. This prospective series differs from previous works on similar subjects insofar as it is a large, homogeneous group of patients treated over a relatively short period of time (30 months) at a single center,
Appendix
For the purpose of this study, a concomitant cardiac disease (cardiac comorbidity) was defined as follows: previous cardiac surgery, previous myocardial infarction, history of coronary artery disease, current treatment for hypertension, arrhythmia, or cardiac failure. All the patients with a concomitant cardiac disease underwent a specialized cardiac evaluation before performing the stair climbing test, and they were allowed to perform the test only when deemed in a hemodynamically stable
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None of the authors have any conflicts of interest to disclose.
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