MiscellaneousRelation of Biomarkers and Cardiac Magnetic Resonance Imaging After Marathon Running
Section snippets
Methods
A prospective study was performed on 14 amateur healthy volunteers participating in the 2008 Manitoba Marathon. Study subjects were randomly recruited, and written informed consent was obtained after local institutional board approval from the University of Manitoba. Subjects aged 18 to 45 years participating in the marathon (26.2 mi) were included. Patients with preexisting cardiovascular risk factors, including diabetes, hypertension, smoking, elevated lipids, and family histories of
Results
A total of 762 participants (545 men, 217 women) completed the 2008 Manitoba Marathon, with a mean finishing time of 254 ± 43 minutes. Our study population included 14 patients (mean age 33 ± 6 years), of whom 8 were men and 6 were women. Most patients (n = 10) were moderately trained, having run <40 mi/week (mean 26 ± 8 mi/week), and the remaining 4 were highly trained (mean 53 ± 12 mi/week). The mean time to completion of the full marathon was 245 ± 68 minutes. The subjects' weights, heights,
Discussion
In the present study, we confirmed the findings of previous studies that there is a significant increase in cardiac biomarkers of injury after prolonged exercise,6, 7, 8, 9, 10 with 100% of the participants demonstrating positive troponin levels. There was echocardiographic evidence of LV and RV diastolic dysfunction after completion of the marathon that had not completely normalized at 1-week follow-up. The RV systolic dysfunction detected by echocardiography after the marathon was validated
Acknowledgment
We would like to acknowledge and express our gratitude for the gracious support provided by management staff and volunteers of the 2008 Manitoba Marathon.
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The work was supported by funding from the St. Boniface General Hospital and Research Foundation, Winnipeg, Manitoba, Canada.