MiscellaneousRelation of Season and Temperature to Endothelium-Dependent Flow-Mediated Vasodilation in Subjects Without Clinical Evidence of Cardiovascular Disease (from the Framingham Heart Study)†
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Participants
The design of the Framingham Offspring Study has been described elsewhere.15 Participants receiving the seventh examination (1998 to 2001) were eligible for the present investigation (n = 3,539; 86% of those alive at examination 7). A total of 2,587 participants (73% of those eligible) were available for FMD analyses after exclusions for the following indications: room temperature not recorded at the time of examination (n = 237), missing data for outdoor temperature on examination day (n =
Participant characteristics
Characteristics of the 2,587 eligible participants (1,973 with flow velocity data) from the Framingham Offspring Cohort (53% women, mean age 61 ± 10 years), categorized by season, are listed in Table 1. The vascular measurements were made from 8 a.m. to 1 p.m., and the mean time of the study did not vary according to season (p = 0.55). In winter, participants had higher systolic and diastolic blood pressures (unadjusted). Participants examined during winter and spring were younger than those
Discussion
In the Framingham Offspring Cohort, we observed that brachial artery FMD was lowest in winter and that the relation between season and this measure of conduit artery endothelial function remained significant after adjusting for clinical covariates and baseline flow velocity. Whereas conduit artery dilator function related most strongly to season, we observed that microvascular vasodilator function, as assessed by hyperemic flow, was more strongly related to ambient temperature. Thus, reactive
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This study was supported by Grants N01-HC 25195, HL60040, HL70100, and K24-HL-04334 (to Dr. Vasan) from the National Heart, Lung, and Blood Institute, Bethesda, Maryland, and the Donald W. Reynolds Foundation, Las Vegas, Nevada. Cardiovascular Engineering, Inc., Waltham, Massachusetts, provided image-capture software.
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Conflict of interest: Dr. Mitchell is president of Cardiovascular Engineering, Inc.