Clinical investigation: outcomes, health policy, and managed careThe peripheral artery questionnaire: a new disease-specific health status measure for patients with peripheral arterial disease☆
Section snippets
Development of the PAQ
The PAQ (Appendix) was modeled after previous disease-specific cardiovascular instruments.13, 14 It was developed after review of the medical literature, examination of available health status measures, focus groups with experienced clinicians, and unstructured interviews with patients. To make the instrument specific to PAD, patients are asked to rate each question in terms of the limitations that they had as the result of symptoms of inadequate lower extremity perfusion. By referencing a
Results
Forty-four patients agreed to participate in this study. Mean age of participants was 68 ± 11, and 55% were men. The following comorbid conditions were present: 39% had diabetes, 86% had hypertension, 27% had had a prior peripheral revascularization procedure (23% in the same leg and 2% in the opposite leg), 2% had a history of congestive heart failure, and 9% had chronic obstructive lung disease; 66% of the patients had a history of smoking, and 25% continued to smoke at the time of the study.
Discussion
Quantifying the impact of PAD from the patient's perspective is an essential component of evaluating new pharmacologic and revascularization treatments. The measurement of health status is particularly important, given that other outcomes such as limb amputation and death are relatively rare in the current era.6 This study describes a new disease-specific health status measure for patients with PAD. The individual domains of the PAQ appear to be valid in that expected correlations with other
References (25)
- et al.
Monitoring the quality of life in patients with coronary artery disease
Am J Cardiol
(1994) - et al.
The importance of increasing public and physician awareness of peripheral arterial disease
J Vasc Interv Radiol
(2002) - et al.
Current medical therapies for patients with peripheral arterial diseasea critical review
Am J Med
(2002) Selecting end points in clinical trialswhat evidence do we really need to evaluate a new treatment?
Am Heart J
(2001)- et al.
Development and evaluation of the Kansas City Cardiomyopathy Questionnairea new health status measure for heart failure
J Am Coll Cardiol
(2000) - et al.
Development and evaluation of the Seattle Angina Questionnairea new functional status measure for coronary artery disease
J Am Coll Cardiol
(1995) - et al.
Methods to explain the clinical significance of health status measures
Mayo Clin Proc
(2002) - et al.
Measuring health-related quality of life
Ann Intern Med
(1993) - et al.
Management of peripheral arterial disease (PAD)TASC Working Group: TransAtlantic Inter-Society Concensus (TASC)
J Vasc Surg
(2000) - et al.
Effect of cilostazol in patients with intermittent claudicationa randomized, double-blind, placebo-controlled study
Vasc Endovasc Surg
(2002)
Medical treatment of peripheral arterial disease and claudication
N Engl J Med
Diagnosis and treatment of chronic arterial insufficiency of the lower extremitiesa critical review
Circulation
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Research grants for this project were provided by the Max Baer Foundation from the Prairie Heart Institute, Springfield, Mo, and the Saint Luke's Foundation, Kansas City, Mo.