Age-related changes in carotid artery wall properties in men

doi:10.1016/0301-5629(86)90218-8

Ultrasound in Medicine & Biology

Volume 12, Issue 6, June 1986, Pages 465-471

https://doi.org/10.1016/0301-5629(86)90218-8 Get rights and content

Abstract

Changes in distensibility and cross-sectional compliance of the common carotid artery with age were studied in 80 presumed healthy volunteers, varying in age between 20 and 69 y. The distensibility was assessed from the relative increase in arterial diameter during systole normalized with respect to the arterial pulse pressure. The cross-sectional compliance was obtained by multiplying the distensibility by the arterial diameter. The relative diameter changes of the common carotid artery during the cardiac cycle were recorded on-line with a high resolution multigate pulsed Doppler system. The arterial diameter was assessed from the width of the velocity profiles which can also be recorded on-line with this system. Arterial pulse pressure was determined from brachial artery cuff blood pressure measurements. Both distensibility and cross-sectional compliance of the common carotid artery decreased linearly with age, starting in the third age decade. The reduction in the latter parameter was less pronounced, probably as a consequence of an increase in arterial diameter with age.

References (21)

A.P.G. Hoeks et al.
Transcutaneous detection of relative changes in artery diameter
Ultrasound in Med. & Biol.
(1985)
R.S. Reneman et al.
Local Doppler audio spectra in normal and stenosed carotid arteries in man
Ultrasound in Med. & Biol.
(1979)
B.T. Altura et al.
Pentobarbital and contraction of vascular smooth muscle
Am. J. Physiol.
(1975)
J.O. Arndt et al.
The diameter of the intact carotid artery in man and its change with pulse pressure
Pfluegers Arch.
(1968)
D.H. Bergel
Cardiovascular Fluid Dynamics
(1972)
W.J. Dixon et al.
Biomedical Computer Program P-Series
(1981)
B.S. Gow et al.
The elasticity of canine and human coronary arteries with reference to postmortem changes
Circ. Res.
(1979)
A.P.G. Hoeks et al.
A multigate pulsed Doppler system with serial data processing
IEEE Trans. Sonics Ultrasonics SU-28
(1981)
A.P.G. Hoeks et al.
A novel frequency estimator for sampled Doppler signals
IEEE Trans. Biomed. Eng. BME-31
(1984)
K.G. Joreskog et al.

There are more references available in the full text version of this article.

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Original contributionAge-related changes in carotid artery wall properties in men

Abstract

Ultrasound in Med. & Biol.

Ultrasound in Med. & Biol.

Pentobarbital and contraction of vascular smooth muscle

Am. J. Physiol.

The diameter of the intact carotid artery in man and its change with pulse pressure

Pfluegers Arch.

Cardiovascular Fluid Dynamics

Biomedical Computer Program P-Series

The elasticity of canine and human coronary arteries with reference to postmortem changes

Circ. Res.

A multigate pulsed Doppler system with serial data processing

IEEE Trans. Sonics Ultrasonics SU-28

A novel frequency estimator for sampled Doppler signals

IEEE Trans. Biomed. Eng. BME-31

Original contribution
Age-related changes in carotid artery wall properties in men