Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain

doi:10.1016/0006-8993(96)00273-9

Brain Research

Volume 726, Issues 1–2, 8 July 1996, Pages 49-56

https://doi.org/10.1016/0006-8993(96)00273-9 Get rights and content

Abstract

Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) support the viability and function of many types of neurons, and are likely mediators of activity-dependent changes in the CNS. We examined BDNF and NGF mRNA levels in several brain areas of adult male rats following 0, 2, 4, or 7 nights with ad libitum access to running wheels. BDNF mRNA was significantly increased in several brain areas, most notably in the hippocampus and caudal13 of cerebral cortex following 2, 4, and 7 nights with exercise. Significant elevations in BDNF mRNA were localized in Ammon's horn areas 1 (CAI) and 4 (CA4) of the hippocampus, and layers II–III of the caudal neocortex and retrosplenial cortex. NGF mRNA was also significantly elevated in the hippocampus and caudal13 of the cortex, affecting primarily the dentate gyrus granular layer (DG) and CA4 of the hippocampus and layers II–III in caudal neocortex.

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Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain

Abstract

Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture

Neuron

Viktor Hamburger Award review. Environmental regulation of brain trophic interactions

Int. J. Dev. Neurosci.

Effects of physical conditioning on information-processing efficiency

Percept. Mot. Skills

Long-term effects of exercise on psychological functioning in older men and women

J. Gerontol.

Activation of basal forebrain cholinergic neurons differentially regulates brain-derived neurotrophic factor mRNA expression in different projection areas

Neurosci. Lett.

Muscle respiratory capacity and V02 max in identically trained young and old rats

J. Appl. Physiol.

The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus

Neuroreport

Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex

NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis

Neuron

Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: prevention by NGF and bFGF

Exp. Neurol.

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

Anal. Biochem.

Relationships between physical exercise and cognitive abilities in older adults

Psychol. Aging

Glucocorticoids depress activity-dependent expression of BDNF mRNA in hippocampal neurones

Neuroreport

Neural Plasticity and Regeneration

Effects of stress and exercise on rat hippocampas and striatum extracellular lactate

Am. J. Physiol.

Hormonal and metabolic responses of untrained, moderately trained, and highly trained men to three exercise intensities

Metabolism

Endogenous NGF and nerve impulses regulate the collateral sprouting of sensory axons in the skin of the adult rat

J. Neurosci.

Rat cortical morphology following crowded-enriched living conditions

Exp. Neurol.

Plasticity in the 904-day-old male rat cerebral cortex

Exp. Neurol.

The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons

Neuron

Age and fitness effects on EEG, ERPs, visual sensitivity, and cognition

Neurobiol. Aging

The hippocampus-what does it do?

Behav. Neural Biol.

P3 latency and symbol digit performance correlations in aging

Exp. Aging Res.

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

Nature

Compensation of the age-related decline in hippocampal muscarinic receptor density through daily exercise or underfeeding

J. Gerontol.

Seizure-induced changes in neurotrophin expression: implications for epilepsy

Exp. Neurol.

Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons

Science

The effects of exercise training on [3H]spiperone binding in rat striatum

Pharmacol. Biochem. Behav.

Exercise and sport in mental health: a review of the literature

Isr. J Psychiatry Relat. Sci.