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The impact of obesity on egg quality

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Abstract

Obesity in women is a concern in many countries. This causes numerous health issues; however, this review focuses on the impact of obesity on women’s reproduction, and in particular the oocyte. Data from infertility clinics and experimental animal models that address the effects of obesity are presented. Bidirectional communication and metabolic support from the surrounding cumulus cells are critical for oocyte development, and the impact of obesity on these cells is also addressed. Both oocyte maturation and metabolism are impaired due to obesity, negatively impacting further development. In addition to reproductive hormones, obesity induced elevations in insulin, glucose, or free fatty acids, and changes in adipokines appear to impact the developmental competence of the oocyte. The data indicate that any one of these hormones or metabolites can impair oocyte developmental competence in vivo, and the combination of all of these factors and their interactions are the subject of ongoing investigations.

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  1. Department of Obstetrics and Gynecology, Washington University in St. Louis, 660 South Euclid Ave., St. Louis, MO, 63110, USA

    Scott H. Purcell & Kelle H. Moley

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  1. Scott H. Purcell
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Correspondence to Kelle H. Moley.

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Clinical and experimental data indicate that through various mechanisms obesity has a negative impact on oocyte maturation and metabolism, which affect subsequent development.

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Purcell, S.H., Moley, K.H. The impact of obesity on egg quality. J Assist Reprod Genet 28, 517–524 (2011). https://doi.org/10.1007/s10815-011-9592-y

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