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Alterations in plasma-volume-corrected blood components of marathon runners and concomitant relationship to performance

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Summary

The study was undertaken to determine the effects of running a marathon on concentration of various blood components resulting from phenomena other than fluid loss, and these were related to performance times. Twenty male marathon runners ranging from 20 to 50 years of age participated in the study. Blood samples were collected before and after the subjects ran in a marathon. Blood samples were analyzed for sodium, potassium, glucose, lactate dehydrogenase, creatinine, creatine phosphokinase, triglycerides, cholesterol, hematocrit, hemoglobin, protein, white blood cell number, uric acid, carbon dioxide, and iron. All of the blood parameters increased significantly in concentration with the exceptions of glucose and carbon dioxide which decreased. After accounting for plasma-volume loss (COR), there remained significant increases in blood serum lactate dehydrogenase, creatinine, creatine phosphokinase, uric acid, iron, and whole-blood white blood cell number. Significant decreases in COR serum sodium, protein, glucose, and carbon dioxide were found. Lactate dehydrogenase and creatine phosphokinase concentration changes support the concept of acute damage to muscle tissue resulting from marathon running. No strong relationship between performance time and other measured variables was found. COR measures were more representative of marathon induced blood changes from physiological dynamics other than plasma volume change than presently reported findings.

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References

  • Apple FS, Rogers MA, Sherman WM, Ivy JL (1984) Comparison of serum creatine kinase and creatine kinase MB activities post-marathon versus post-myocardial infarction. Clin Chim Acta 138:111–118

    Google Scholar 

  • Dill DB, Costill DL (1974) Calculation of percentage changes in volumes of blood plasma, and red cells in dehydration. J Appl Physiol 37:247–248

    Google Scholar 

  • Hagerman FC, Hikada RS, Staron RS, Sherman WM, Costill DL (1984) Muscle damage in marathon runners. Physic Sports Med 12:39–46

    Google Scholar 

  • Hunter JB, Critz JB (1971) Effect of training on plasma enzyme levels in man. J. Appl Physiol 31:20–23

    Google Scholar 

  • Kieblock AJ, Manjoo M, Boyens J, Katzeff IE (1979) Creatine phosphokinase and lactate dehydrogenase levels after ultra long-distance running. An analysis of isoenzyme profiles with special reference to indicators of myocardial damage. S Afr Med J 55:1061–1069

    Google Scholar 

  • Krebs P, Scully BC, Zinkgraf SA (1983) The acute and prolonged effects of marathon running on 20 blood parameters. Physic Sports Med 11:66–73

    Google Scholar 

  • Kussi T, Kostiainen E, Vartiainen E, Pitkanen L, Ehnolhm C, Koshonen HJ, Nissinen A, Puska P (1984) Acute effects of marathon running on levels of serum lipoproteins and androgenic hormones of healthy males. Metabolism 33:527–531

    Google Scholar 

  • Lemon PR, Mullin JP (1980) Effect of initial glycogen levels on protein catabolism during exercise. J Appl Physiol: Respir Environ Exercise Physiol 48:624–629

    Google Scholar 

  • Levine SA, Gordon B, Derick CL (1924) Some changes in the chemical constituents of the blood following a marathon race. JAMA 82:1778–1779

    Google Scholar 

  • Magazanik A, Meytes Y, Meytes D, Meytes I (1974) Enzyme blood levels and water balance during a marathon race. J Appl Physiol 36:214–217

    Google Scholar 

  • Margaria R, Cerretelli P, Aghemo P, Sassi G (1963) Energy cost of running. J Appl Physiol 18:367–370

    Google Scholar 

  • Maron MB, Horvath SM (1978) The marathon: a history and review of the literature. Med Sci Sports Exerc 10:137–150

    Google Scholar 

  • Maron MB, Horvath SM, Wilkerson JE (1975) Acute blood biochemical alteration in response to marathon running. Eur J Appl Physiol 34:173–181

    Google Scholar 

  • Maron MB, Horvath SM, Wilkerson JE (1977) Blood chemical alterations during recovery from a competitive marathon running. Eur J Appl Physiol 36:231–238

    Google Scholar 

  • Maughan RJ, Leiper JB (1983) Aerobic capacity and fractional utilization of aerobic capacity in elite and non-elite male and female marathon runners. Eur J Appl Physiol 52:80–87

    Google Scholar 

  • Myhre LG, Hartung GH, Tucker DM (1982) Plasma volume and blood metabolites in middle aged runners during a warm weather marathon. Eur J Appl Physiol 48:227–240

    Google Scholar 

  • Riley WJ, Pyke FS, Roberts AD, England JF (1975) The effects of long-distance running on some biochemical variables. Clin Chim Acta 65:83–89

    Google Scholar 

  • Rose LI, Brouser JE, Cooper KH (1970) Serum enzymes after marathon running. J Appl Physiol 29:355–357

    Google Scholar 

  • Senay LC, Rogers G, Jooste P (1980) Changes in blood plasma during progressive treadmill and cycle exercise. J Appl Physiol 49:59–65

    Google Scholar 

  • Shapiro Y, Magazanik A, Sohar E, Reich CB (1973) Serum enzyme changes in untrained subjects following a prolonged march. Can J Physiol Pharmacol 51:271–276

    Google Scholar 

  • Siegel AJ, Silverman LM, Lopes RM (1980) Creatine kinase elevations in marathon runners: relationship to training and competition. Yale J Biol Med 53:275–279

    Google Scholar 

  • Stansbie D, Tomlinson K, Potman JM, Walters EG (1982) Hypothermia, hyperkalemia, and marathon running. Lancet 2:1336

    Google Scholar 

  • Technicon SMA 6–60 Multichannel Biochemical Analyzer (1974). Technical Publication Number UA4-0317A00. Technicon Instruments Corporation, Terrytown, New York

  • Technicon SMA 12–60 Multichannel Biochemical Analyser (1976) Technical Publication Number UA4-0160-10. Technicon Instruments Corporation, Terrytown, New York

  • Wells CL, Stern JR, Hecht LH (1982) Hematological changes following a marathon race in male and female runners. Eur J Appl Physiol 48:41–49

    Google Scholar 

  • Wells CL, Schrader TA, Stern JR, Krahenbuhl GS (1985) Physiological responses to a 20-mile run under three fluid replacement treatments. Med Sci Sports Exerc 17:364–369

    Google Scholar 

  • Whiting RH, Maushan RJ, Miller JD (1984) Dehydration and serum biochemical changes in marathon runners. Eur J Appl Physiol 52:183–187

    Google Scholar 

  • Wilkerson JE, Gutin B, Horvath SM (1977) Exercise-induced changes in blood, red cell, and plasma volumes in man. Med Sci. Sports 9:155–158

    Google Scholar 

  • Wilkerson JE, Kolka MA, Stephenson LA (1979) Exercise-induced leukocytosis during a competitive marathon. Med Sci Sports Exerc 11:99

    Google Scholar 

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Kraemer, R.R., Brown, B.S. Alterations in plasma-volume-corrected blood components of marathon runners and concomitant relationship to performance. Europ. J. Appl. Physiol. 55, 579–584 (1986). https://doi.org/10.1007/BF00423200

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