Table 1

Mendelian randomisation (MR) results for the putative effect of sedentary behaviour and physical activity on visceral adipose tissue

ExposureSelf-reportAccelerometer
SNPs (#)Effect95% CISNPs (#)Effect95% CI
Sedentary behaviour
 IVW1280.24***0.20 to 0.2940.15−0.01 to 0.31
 MVMR0.38***0.27 to 0.490.04−0.14 to −0.23
 MR-Egger0.34**0.13 to 0.560.00−0.69 to 0.69
 Weighted mode0.24***0.13 to 0.360.03−0.17 to 0.24
 Weighted median0.24***0.20 to 0.280.07−0.07 to 0.22
 MR-PRESSO0.30***0.21 to 0.380.12−0.06 to 0.30
 CAUSE0.23***0.19 to 0.280.1−0.01 to 0.21
Moderate PA
 IVW320.08−0.01 to 0.17
 MVMR0.14−0.07 to 0.36
 MR-Egger0.08−0.21 to 0.38
 Weighted mode0.04−0.13 to 0.21
 Weighted median0.03−0.05 to 0.12
 MR-PRESSO0.13−0.08 to 0.33
 CAUSE0.250.02 to 0.47
MVPA
 IVW93−0.09**−0.14 to −0.0346−0.14***−0.19 to −0.08
 MVMR0.05−0.09 to 0.19−0.12**−0.19 to −0.04
 MR-Egger−0.18−0.4 to 0.03−0.09−0.24 to 0.06
 Weighted mode−0.04−0.17 to 0.09−0.03−0.18 to 0.11
 Weighted median−0.07−0.12 to −0.01−0.09**−0.16 to −0.03
 MR-PRESSO−0.08−0.21 to 0.050.00−0.03 to 0.03
 CAUSE−0.06−0.16 to 0.04−0.11***−0.15 to −0.07
Vigorous PA
 IVW61−0.31***−0.31 to −0.1326−0.19***−0.25 to −0.13
 MVMR−0.02−0.34 to 0.29−0.15***−0.24 to −0.07
 MR-Egger0.05−0.2 to 0.3−0.24−0.51 to 0.02
 Weighted mode−0.09−0.34 to 0.15−0.23−0.39 to −0.06
 Weighted median−0.14**−0.24 to −0.04−0.19***−0.28 to −0.1
 MR-PRESSO−0.12−0.40 to 0.16−0.09−0.16 to −0.02
 CAUSE−0.13−0.33 to 0.06−0.14***−0.19 to −0.08
SSOE*/overall PA†
 IVW98−0.37***−0.47 to −0.276−0.28−0.49 to −0.06
 MVMR−0.27−0.52 to −0.01−0.21−0.44 to 0.02
 MR-Egger−0.09−0.45 to 0.26−0.25−1.08 to 0.57
 Weighted mode−0.37−0.73 to 0.0−0.17−0.39 to 0.06
 Weighted median−0.31***−0.41 to −0.21−0.21−0.38 to −0.03
 MR-PRESSO−0.33**−0.55 to −0.11−0.05−0.16 to 0.05
 CAUSE−0.28−0.46 to −0.11−0.08−0.19 to 0.03
  • ***P<0.001, **p<0.01.

  • *Analyses only conducted for self-report PA.

  • †Analyses only conducted for accelerometer-measured PA.

  • .CAUSE, causal analysis using summary effect; IVW, inverse variance weighted; MVMR, multivariable MR; MVPA, moderate-to-vigorous PA; PA, physical activity; PRESSO, pleiotropy residual sum and outlier; SNPs, single nucleotide polymorphisms; SSOE, strenuous sports and other exercises.