Table 1

How the physical activity programme in the Lifestyle Interventions and Independence for Elders (LIFE) clinical trials was adapted and tailored in this pilot study of older adults with metastatic gastrointestinal cancer

LIFE clinical trials16 17Pilot study adaptation
2×/week supervised activitySupervised activity during chemotherapy infusions (1×/week or alternate weeks)
Group-based counsellingIndividual (1 on 1) counselling
1×/month phone counselling1×/week telephone counselling
Progression of intensity of activity over first 2–3 weeksProgression of intensity of activity over first 4–6 weeks
SymptomPilot study tailoring
  • Peripheral neuropathy

  • Feet: substitute non-weight bearing activity

  • Hands: practise safe holding of weights

  • Cancer-related fatigue

  • Fatigue diary to determine daily trajectory of fatigue

  • Promote activity during less fatigued intervals

  • Emphasis on aerobic activity

  • Gastrointestinal (eg, nausea, diarrhoea)

  • Promote hydration

  • Reduce activity performed alone

  • Permit ‘rest and recovery’ day