The association between incident knee injuries (n=10) and changes in pain, function and MRI abnormalities over the season
| Outcome variables | Incident knee injuries | |
| Univariable | Multivariable* | |
| β (95% CI) | β (95% CI) | |
| Change in VAS | 27.53 (14.43 to 40.62) | 29.57 (16.41 to 42.74) |
| Change in KOOS total | 25.97 (16.32 to 35.63) | 26.48 (16.08 to 36.88) |
| KOOS subscales | ||
| Change in symptoms | 1.58 (−0.27 to 3.43) | 1.68 (−0.18 to 3.54) |
| Change in stiffness | 1.55 (0.84 to 2.26) | 1.61 (0.89 to 2.33) |
| Change in pain | 5.58 (3.46 to 7.70) | 5.72 (3.45 to 7.98) |
| Change in function | 8.64 (4.83 to 12.46) | 8.73 (4.90 to 12.56) |
| Change in sport | 4.65 (2.41 to 6.90) | 4.69 (2.47 to 6.91) |
| Change in quality of life (QOL) | 3.96 (2.61 to 5.31) | 4.05 (2.56 to 5.55) |
| Change in synovial membrane thickness | 0.12 (−0.005 to 0.25) | 0.12 (−0.02 to 0.25) |
| Change in synovial fluid volume | 3.07 (−1.39 to 7.51) | 3.34 (−1.20 to 7.87) |
| Univariable | Multivariable* | |
| RR (95% CI) | RR (95% CI) | |
| Development of a new or enlarging BML† | 2.98 (1.73 to 5.14) | 2.93 (1.47 to 5.87) |
| Incident cartilage defects‡ | 6.33 (1.04 to 38.51) | 5.12 (0.35 to 75.39) |
| Incident meniscal damage (tear, partial or full extrusion) | 4.84 (1.37 to 17.15) | 3.96 (1.07 to 14.63) |
| Incident effusion synovitis‡ | 0.90 (0.11 to 7.49) | 0.28 (0.004 to 19.25) |
Changes in pain, function and MRI abnormalities are the outcome in these analyses.
RR represents the risk of worsening MRI abnormalities in those who had an incident knee injury.
Boldface denotes statistically significant result.
β coefficient represents the difference in change scores in those who did and did not report an incident knee injury.
*Adjusted for age, weight and height.
†Defined as an increase >25 mm2 in total size.
‡Defined as a new cartilage defect/effusion synovitis in those with a score <2 at baseline.
BML, bone marrow lesion; KOOS, knee injury and osteoarthritis outcome score; VAS, visual analogue scale.