Table 2

Studies that evaluate PA and proposed potential underlying biological mechanisms

RefAuthorYear of publicationCountryAim/purposeStudy populationStudy designPA type+durationOutcomesProposed biological mechanism
31Banerjee S, Manley K, Shaw B, Lewis L, Cucato G, Mills R, Rochester M, Clark A and Saxton J M2018UKTo evaluate the feasibility of vigorous intensity aerobic interval exercise in patients with BC prior to radical cystectomy.Patients with BC patients prior to radical cystectomy (n=60).RCTTwice-weekly preoperative supervised vigorous intensity aerobic interval exercise in addition to standard treatment.Improvements in oxygen pulse and power output were observed at the follow-up CPET in the exercise group vs controls.Presurgical aerobic interval exercise and the improvements in cardiopulmonary fitness variables could have important implications for postoperative recuperation after RC.
34Banerjee, S, Manley, K, Thomas, L, Shaw B, Saxton J, Mills R and Rochester M2013UKTest the effect of a short preoperative course of supervised exercise in cardiopulmonary fitness.Patients with BC who underwent radical cystectomy (n=30).RCTPatients in the intervention arm were offered twice weekly supervised exercise sessions preoperatively for 4 weeks, while the control arm had standard care.In the control group, VO2 max was 22.8 (12.9–41.0) mL/kg/min, and the mean change was 0.48 mL/kg/min (95% CI −0.71 to 1.67) following the intervention. In the intervention arm, initial average VO2 max was 20.38 mL/kg/min, which increased to an average of 25.5 mL/kg/min.Patients comply with a supervised exercise regime, and there seems to be an improvement in their cardiorespiratory fitness.
  • BC, bladder cancer; CPET, cardiopulmonary exercise testing; PA, physical activity; RC, radical cystectomy; RCT, randomised clinical trial; VO2, maximum rate of O2 consumption.