Description and calculation of domain scores for CNS vital signs
| Clinical domain | Test | Domain score calculation | Domain description |
| Psychomotor speed | FTT, SDC | FTT total taps average +SDC correct responses | Ability to perceive, attend and respond to complex visual–perceptual information and perform simple fine motor tasks. |
| Reaction time | ST | (ST complex reaction time correct+ST reaction time correct)/2 | Speed of reaction to a simple and increasingly complex set of directions. |
| Complex attention | CPT, SAT, ST | ST commission errors+SAT errors+CPT errors | Ability to track and respond to a variety of stimuli over lengthy periods of time and/or perform complex mental tasks requiring vigilance quickly and accurately. |
| Cognitive flexibility | SAT, ST | SAT correct responses−SAT errors−ST commission errors | Ability to adapt to a rapidly changing and increasingly complex set of directions and/or to manipulate the information. |
| Processing speed | SDC | SDC correct responses−SDC errors | Ability to recognise and process information, that is, perceiving/ responding to incoming information, motor speed, fine motor coordination, visual–perceptual ability. |
| Verbal memory | VBM | Correct hits and passes immediate+correct hits and passes delay | Ability to remember (recognise and retrieve) words. |
| Visual memory | VIM | Correct hits and passes immediate+correct hits and passes delay | Ability to remember (recognise and retrieve) geometric figures. |
CPT, Continuous Performance Test; FTT, Finger Tapping Test; SAT, Shifting Attention Test; SDC, Symbol Digit Coding Test; ST, Stroop Test; VBM, Verbal Memory Test; VMT, Visual Memory Test.