Table 3

Baseline sea-level characteristics

PlaceboLosartanP valueACE genotype and pair no.
Female pairsMale pairs
Age (years)38.6±18.540.4±18.00.831IDID4IIII
Body mass (kg)74.1±11.566.7±13.30.712IDID5IIII
Height (cm)172.6±8.4176.4±8.90.833IDID6IDID
GFR (mL/min/1.73 m2)88.0±15.290.8±15.80.697IDID
eGFR (mL/min/1.73 m2)87.8±15.390.8±15.90.688IDID
Creatinine (μmol/L)*84.5±24.081.0±31.00.589DDID
  • Baseline results were obtained at sea level and prior to the administration of placebo and losartan. Results for continuous variables are reported as mean±SD unless indicated by *, where values are reported as median ± IQR. ACE genotypes are presented as allelic variations (II, ID and DD). Significance was set to p value <0.05. No significant differences between groups were evident at baseline sea level. Subjects were equally matched for sex (men and women). All genotypes were observed and 90% matched.

  • eGFR, estimated glomerular filtration rate (calculated using the MDRD study equation); GFR, glomerular filtration rate; MDRD, Modification of Diet in Renal Disease.