Maximal exercise test results compared between groups at baseline and twice at altitude
| Placebo | Losartan | P value | |
| Sea-level exercise | |||
| HRmax (bpm) | 171.7±16.5 | 173.7±22.9 | 0.82 |
| Absolute Wattmax (W) | 243±66 | 238±70 | 0.89 |
| Relative Wattmax (W) | 3.3±0.5 | 3.1±0.5 | 0.41 |
| Placebo | Losartan | P value | Placebo +acetazolamide | P value | |
| Altitude exercise | |||||
| Pre-exercise | |||||
| HR (bpm) | 80±12 | 76±15 | 0.50 | 78±14 | 0.10 |
| SBP (mm Hg) | 162±28 | 159±22 | 0.82 | 149±22 | 0.17 |
| DBP (mm Hg) | 79±6 | 76±12 | 0.22 | 76±8 | 0.61 |
| SpO2 (%) | 76±7 | 78±5 | 0.40 | 84±4 | <0.01* |
| Maximal exercise | |||||
| HRmax (bpm) | 152±24 | 143±35 | 0.78 | 147±21 | 0.63 |
| SBP at Wattmax (mm Hg) | 229±47 | 221±50 | 0.81 | 232±47 | 0.43 |
| ΔSBP (mm Hg) | 70±31 | 66±42 | 0.80 | 82±46 | 0.26 |
| DBP at Wattmax (mm Hg) | 87±13 | 85±19 | 0.81 | 96±15 | 0.08 |
| ΔDBP (mm Hg) | 8±10 | 9±11 | 0.93 | 19±14 | 0.04 * |
| SpO2 at Wattmax (%) | 70±5 | 71±7 | 0.89 | 77±4 | <0.01* |
| Wattmax (W) | 155±52 | 138±55 | 0.53 | 149±46 | 0.71 |
| Wattmax(W/kg) | 2.1±0.6 | 1.8±0.5 | 0.23 | 2.0±0.5 | 0.18 |
Values are presented as mean±SD. Change (Δ) SBP and ΔDBP represent the differences between pre-exercise and Wattmax measurements.
*Represents a significant (p≤0.05) difference between placebo and placebo +acetazolamide altitude exercise tests (n=9; within-individual comparisons).
DBP, diastolic blood pressure; HR, heart rate (bpm); HRmax, maximal heart rate; SBP, systolic blood pressure (mm Hg); SpO2, oxygen saturation pulse oximetry (%); Wattmax, wattage at volitional fatigue (presented in absolute, W, and relative, W/kg, units.