Table 1

The mean scores for the Tri-dimensional Personality Questionnaire (TPQ) dimensions; novelty seeking (NS), harm avoidance (HA) and reward dependence (RD), between the DRD2 rs12364283 (A>G), DRD2 rs1076560 (C>A) and DRD4 rs1800955 (T>C) genotypes

TPQ dimensions DRD2 rs12364283P value DRD2 rs1076560P value DRD4 rs1800955P value
AAAGGGCCCAAATTCTCC
Junior
 N(66)(8)(2)(55)(23)(3)(27)(28)(11)
 NS15.7±4.4 (66)13.1±3.6 (8)13.5±6.4 (2)0.24015.0±4.2 (54)16.1±4.9 (20)14.7±4.9 (3)0.58916.8±3.8 (26)16.1±4.2 (26)14.1±5.0 (11)0.201
 HA11.3±5.8 (66)10.4±5.5 (8)11.5±5.0 (2)0.90811.5±5.5 (52)11.0±5.7 (23)15.7±8.6 (3)0.44211.0±5.4 (25)9.9±6.1 (28)12.6±4.6 (11)0.401
 RD†18.1±4.4 (66)15.9±4.4 (8)22.5±2.1 (2)0.07917.7±4.3 (55)18.2±4.7 (20)18.7±3.2 (3)0.85915.5±4.2 (24)20.4±3.6 (28)18.9±3.1 (11) <0.001 (<0.001)*
  RD12.8±1.0 (27)4.1±0.8 (30)3.3±1.0 (11) <0.001 (<0.001)*
  RD25.6±2.1 (27)6.0±1.6 (28)6.1±2.0 (11)0.629
  RD35.4±2.5 (24)7.6±2.2 (31)6.6±1.9 (11) 0.003
(0.002)*
  RD42.0±1.1 (27)2.8±1.1 (31)2.9±1.1 (11) 0.005 (0.002)*
Senior
 N(116)(26)(102)(31)(5)(40)(73)(26)
 NS16.4±5.6 (113)14.6±4.0 (26)0.06815.9±4.9 (100)16.6±6.5 (31)19.3±8.6 (4)0.40515.9±4.7 (39)16.0±5.7 (72)17.2±5.2 (26)0.710
 HA10.0±6.0 (116)10.0±4.9 (25)0.86410.7±6.0 (101)8.6±5.3 (31)8.0±2.6 (5)0.1588.5±5.3 (40)10.6±6.4 (73)10.5±4.6 (26)0.170
 RD†19.0±4.2 (116)20.2±4.0 (25)0.20819.0±4.2 (102)20.0±4.2 (30)21.6±2.7 (5)0.23320.0±4.2 (40)18.4±3.9 (73)20.6±4.2 (26) 0.030 (0.010)**
  RD13.7±1.2 (42)3.5±1.1 (73)4.0±1.1 (27)0.122
  RD26.3±1.4 (40)5.8±2.0 (76)6.7±1.6 (28)0.053
  RD37.0±2.3 (41)6.5±2.4 (75)6.5±2.5 (26)0.499
  RD43.1±1.3 (42)2.7±1.3 (76)3.2±1.3 (27)0.237
  • The means±SD are presented with total number (N) of participants given in parentheses. Significant differences between genotypes are highlighted in bold (p<0.05, age-adjusted, generalised linear model).

  • *Post-hocp value:rs1800955 TT vsCC+CT. ** Post-hocp value:rs1800955 CT vsTT+CC.

  • †TheRD main dimension is significantly different, thus the RD subscales (RD1–RD4) are alsodisplayed.