PT - JOURNAL ARTICLE AU - Elias Lehtonen AU - Dominique Gagnon AU - Daniela Eklund AU - Kaisa Kaseva AU - Juha Evert Peltonen TI - Hierarchical framework to improve individualised exercise prescription in adults: a critical review AID - 10.1136/bmjsem-2022-001339 DP - 2022 Jun 01 TA - BMJ Open Sport & Exercise Medicine PG - e001339 VI - 8 IP - 2 4099 - http://bmjopensem.bmj.com/content/8/2/e001339.short 4100 - http://bmjopensem.bmj.com/content/8/2/e001339.full SO - BMJ OPEN SP EX MED2022 Jun 01; 8 AB - Physical activity (PA) guidelines for the general population are designed to mitigate the rise of chronic and debilitating diseases brought by inactivity and sedentariness. Although essential, they are insufficient as rates of cardiovascular, pulmonary, renal, metabolic and other devastating and life-long diseases remain on the rise. This systemic failure supports the need for an improved exercise prescription approach that targets the individual. Significant interindividual variability of cardiorespiratory fitness (CRF) responses to exercise are partly explained by biological and methodological factors, and the modulation of exercise volume and intensity seem to be key in improving prescription guidelines. The use of physiological thresholds, such as lactate, ventilation, as well as critical power, have demonstrated excellent results to improve CRF in those struggling to respond to the current homogenous prescription of exercise. However, assessing physiological thresholds requires laboratory resources and expertise and is incompatible for a general population approach. A case must be made that balances the effectiveness of an exercise programme to improve CRF and accessibility of resources. A population-wide approach of exercise prescription guidelines should include free and accessible self-assessed threshold tools, such as rate of perceived exertion, where the homeostatic perturbation induced by exercise reflects physiological thresholds. The present critical review outlines factors for individuals exercise prescription and proposes a new theoretical hierarchal framework to help shape PA guidelines based on accessibility and effectiveness as part of a personalised exercise prescription that targets the individual.