TY - JOUR T1 - Patterns of endogenous and exogenous ovarian hormone modulation on recovery metrics across the menstrual cycle JF - BMJ Open Sport & Exercise Medicine JO - BMJ OPEN SP EX MED DO - 10.1136/bmjsem-2021-001047 VL - 7 IS - 3 SP - e001047 AU - Stacy T Sims AU - Laura Ware AU - Emily R Capodilupo Y1 - 2021/07/01 UR - http://bmjopensem.bmj.com/content/7/3/e001047.abstract N2 - Introduction As the number of female athletes competing rises globally, training methodologies should reflect sex differences across critical metrics of adaptation to training. Surrogate markers of the autonomic nervous system (ANS) used for monitoring training load are heart rate variability (HRV) and resting heart rate (RHR). The aim was to investigate ovarian hormone effects on standard recovery metrics (HRV, RHR, respiratory rate (RR) and sleep duration) across a large population of female athletes.Methods A retrospective study analysed 362 852 days of data representing 13 535 menstrual cycles (MC) from 4594 respondents (natural MC n=3870, BC n=455, progestin-only n=269) for relationships and/or differences between endogenous and exogenous ovarian hormones on ANS.Results HRV and return to baseline (recovery) decreased as resting HR and RR increased (p<0.001) from the early follicular to the late luteal phase of the MC. Patterning was paradoxical across phases for users of combined hormonal contraception (BC) as compared with the patterning of the MC. HRV and recovery start elevated and drop off quickly during the withdrawal bleed, rising through the active pill weeks (p<0.001). Progestin-only users had similar patterning as the MC. The relationship between normalised recovery and previous day strain is modulated by birth control type. BC exhibited steeper declines in recovery with additional strain-normalised recovery decreases by an additional 0.0055±0.00135 (p<0.001) per unit of strain; with no significant difference between MC and progestin-only (p=0.19).Conclusion The patterning of ANS modulation from ovarian hormones is significantly different between naturally cycling women and those on BC, with the patterning dependent on the type of contraception used.Data are available on reasonable request. The WHOOP data are the property of WHOOP (Boston, Massachusetts, USA). The authors (LW and ERC) are employees of WHOOP and are permitted to access the WHOOP data server. The data are anonymised appropriately; the data used in the study is a backup of the original data and does not include any personally identifiable information. ER -