Health challenges and acute sports injuries restrict weightlifting training of older athletes
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Abstract
Objectives To quantify acute injuries sustained during weightlifting that result in training restrictions and identify potential risk factors or preventative factors in Master athletes and to evaluate potentially complex interactions of age, sex, health-related and training-related predictors of injuries with machine learning (ML) algorithms.
Methods A total of 976 Masters weightlifters from Australia, Canada, Europe and the USA, ages 35–88 (51.1% women), completed an online survey that included questions on weightlifting injuries, chronic diseases, sport history and training practices. Ensembles of ML algorithms were used to identify factors associated with acute weightlifting injuries and performance of the prediction models was evaluated. In addition, a subgroup of variables selected by six experts were entered into a logistic regression model to estimate the likelihood of an injury.
Results The accuracy of ML models predicting injuries ranged from 0.727 to 0.876 for back, hips, knees and wrists, but were less accurate (0.644) for shoulder injuries. Male Master athletes had a higher prevalence of weightlifting injuries than female Master athletes, ranging from 12% to 42%. Chronic inflammation or osteoarthritis were common among both men and women. This was associated with an increase in acute injuries.
Conclusions Training-specific variables, such as choices of training programmes or nutrition programmes, may aid in preventing acute injuries. ML models can identify potential risk factors or preventative measures for sport injuries.
What is already known on this topic
While there are many health benefits of weightlifting and competitions in older adults, there is a risk of injury with physical activity and sports.
Physiological function and performance declines with older age, and thus there can be a higher prevalence of injuries.
What this study adds
Machine learning approaches and expert models were used to investigate complex interactions among sport history, training-specific variables and health-related variables to identify modifiable factors that may prevent injuries in older athletes during their weightlifting career.
Chronic inflammation or osteoarthritis were common among both male and female weightlifters. This was associated with injuries at shoulders, knees, back or wrists.
How this study might affect research, practice and/or policy
Athletes, coaches and health professionals should be aware of the high prevalence of chronic inflammation or osteoarthritis that restricts weightlifting training of Master athletes, and thus older athletes should be screened for this condition.
More education is needed for coaches and athletes to design training and nutrition programmes that optimise health and performance for Master athletes.
Introduction
The health benefits of aerobic and strength-based physical activities for older adults have been highlighted in many research studies and include improving physical health such as cardiovascular function and muscle and bone mass, physical function such as mobility and independent living, and psychological health.1 2 Furthermore, participation in competitive sports is associated with a multitude of physical and psychosocial benefits3–7 with evidence of prevention of chronic diseases8 and better mental health compared with unstructured physical activities.9 However, engaging in physical activities, leisure or competitive, can lead to injuries. In studies on leisure-time physical activity, the risk of accompanying injuries was highest in contact and team sports10 11 and injuries were more likely in vigorous physical activities compared with light-intensity activities.12 In older athletes, mobility is reduced and muscle fibres of older athletes may be susceptible to contraction-induced injury.13 Definitions of injury rates differ in publications.14 15 For example, they can be reported per 1000 hours of training, occurring within a specified time period, requiring medical attention or leading to training disruptions. In our study on Master weightlifters, the definition of injury captured occurrences during their weightlifting career where athletes had restrictions in their weightlifting training, but they may or may not have sought medical care or stopped training completely. Instead, weightlifters could have modified their training by performing exercises that do not burden specific areas of their bodies.
Only a limited number of studies investigated strength training-related injuries. Weight-related injuries seen in emergency department visits were reported as caused by unusual movements or too heavy weights.16 Soldiers who spent more time strength training per week had a greater percentage of injuries over a 1-year period.17 This conflicts with findings where concurrent strength training may reduce the risk of injury.18 Some injuries have minor physical consequences. Overuse syndromes (pain and functional limitations) may not prevent the majority of either sex from training or competing, they may be eager to return to training,10 but the training programme may be altered due to these injuries.14 19 20 However, even with minor consequences, a disruption of sport activities has negative psychological effects on athletes,21 thus it is important to understand how health concerns affect training and to identify factors associated with injuries that may present preventative strategies or could be consequences of injuries.
Master athletes have a long-term engagement in a specific sport, and thus repetitive stress or overuse injuries can occur.22 Olympic-style weightlifting has seen a dramatic increase in participation in recent years.6 It requires the athlete to attempt a lift of maximal weight to achieve the highest combined total of two lifts, which are the clean and jerk and the snatch. Common injury sites in this sport are shoulders, back, hips, knees and wrists.16 18 20 23 Studies on prevalence of injuries and preventative strategies in Master weightlifters whose physical function and performance declines with age are needed. No previous study has investigated acute injuries sustained during weightlifting for Master weightlifters.
The objectives of this study were (1) to quantify acute injuries sustained during weightlifting that resulted in training restrictions and identify potential risk factors or preventative factors in Master athletes and (2) to evaluate potentially complex interactions of age, sex, health-related and training-related predictors of injuries with machine learning (ML) algorithms. We developed separate models for five common injury sites in weightlifting.
Methods
Study population
Participants were 1051 Master weightlifters ages 35–88 years from 6 countries, Australia (AUS), Canada, Germany, Great Britain, Spain and the USA (dataset).24 In June 2021, Masters weightlifters were invited to participate in an online survey through email and newsletters by the national governing bodies of weightlifting, and via online platforms including Facebook and Instagram. The study was described in more detail in Huebner et al.7
Measures
Definition of injury
Definitions of sports injuries differ between studies, such as acute injuries or gradually developing overuse symptoms when athletes continue training.14 15 To capture occurrences where athletes may or may not have sought medical care or have stopped training completely, in this study injuries were defined in relation to participation in weightlifting, namely whether training restriction occurred due to acute injuries sustained during weightlifting. This was a response, ‘yes’ or ‘no’ to the question ‘Have you ever had training restrictions due to acute injuries sustained during or while performing weightlifting?’ Since the survey was conducted during the pandemic when athletes may not have had access to training facilities, the time frame for occurrence of injuries included an athlete’s history of weightlifting.
Information about concurrent training and sport participation prior to starting weightlifting was collected with categories power lifting, ball sports, endurance, fitness, mobility (eg, yoga or Pilates), martial arts, as well as an open-ended question to specify these or other activities. Time for specific elements of weightlifting training included warm-up, classic lifts (snatch, clean and jerk and accessories such as hang snatch or clean from blocks), strength exercises (squats, presses), additional exercises (pull-ups, core, machines, etc) and cool-down with options 0–15 min, 15–30 min, 30–45 min, 45–60 min or more than 60 min. A Likert scale (strongly agree, agree, neither agree nor disagree, disagree, strongly disagree) was used to ask participants whether following a training-specific nutrition programme was important for their weightlifting training (ie, recovery, muscle increase). Survey questions are included in the online supplemental file.
Statistical methods
The purpose of the ML models is the prediction of acute injuries at multiple locations (shoulders, back, hips, knees and wrists) sustained during weightlifting that result in training restrictions and to evaluate the contributions of subgroups of variables on the accuracy of the prediction models. We employed several classification algorithms developed in both the statistical and the ML literature. This included support vector machines, generalised boosted methods, regularised logistic regression, random forests, one-layer neural network and naïve Bayesian methods for classification and prediction. A brief overview is given in the online supplemental file, and more details can be found in Hastie et al.25 The ML algorithms were evaluated by randomly selecting 80% of the sample as the training set and testing the performance on the remaining 20% of the sample.26 We used a 10-fold repeated cross-validation to tune the parameter estimates for each ML algorithm. Accuracy of model performances was compared. A variable importance metric was calculated to ascertain the relative contribution of a particular covariate to the accuracy of the prediction.
In addition, an expert model was constructed by collecting feedback from a group of experienced coaches and athletes, three women and three men, on variables included in this dataset that may potentially be associated with weightlifting injuries. Variables with at least two mentions were included in logistic regression models to obtain estimates for ORs and 95% CIs for each covariate. Due to the serious impact of injuries on health and training, a cut-off p value 0.10 was considered statistically significant, so that important factors will not be missed. All statistical analyses were performed using R v.4.0.3.27
Patient and public involvement
Active Master weightlifters provided feedback on survey questions.
Results
Of the 1051 respondents, 976 had complete data and were included in the analysis (7% missing variables). Women accounted for 51% of the respondents with a median age of 48 years (table 1). Common sites for weightlifting injuries were shoulders (35%), knees (26%), back (23%) and wrists (21%). Less common were hips (13%), elbows (12%) and ankles (2%). Most of the respondents engaged in physical activities or had sport experience prior to starting weightlifting (92%) (online supplemental table S1).
Table 1
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Characteristics of respondents
High blood pressure was more common among men (26%) than women (7%), particular at older ages (figure 1). Morbidities such as cardiovascular disease, diabetes or cancer increased with older age. Chronic inflammation/osteoarthritis was present in all age groups.
Chronic conditions reported by women (green) and men (blue). All except CI were based on the question ‘have you ever had a doctors’ diagnosis of…?’. BP, high blood pressure; C, cancer; CI, chronic inflammation/osteoarthritis; CV, cardiovascular disease; DB, diabetes.
Predictive performance
The prediction performances of the models are evaluated on a holdout set of 195 cases (20% of the cases) (online supplemental figure S1). Injury rates were comparable between the training and test sets (online supplemental table S2). Correlations between predictor variables were low (online supplemental figure S2). The accuracy of ensemble predictions ranged from 0.727 to 0.876 but was less accurate for shoulder injuries at 0.644 (table 2). Classic statistical models (logistic regression) were comparable to the ML models when using all variables. Random forest performed similarly as ensemble predictions for all variables as well as for the subgroup of variables selected by experts.
Table 2
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Performance metrics of the prediction models
Variable importance of predictors
The variable importance metric ascertains the relative contribution of a particular covariate to the accuracy of the prediction but does not indicate whether a variable is a risk factor for injuries. Age-related variables such as age, age at start of weightlifting or years of experience were among the top three predictors for injury locations. Training frequency or length of session for groups of exercises (warm-up, cool-down, supplementary) were also top predictors. Sex, chronic inflammation/osteoarthritis were rated high for shoulder injuries, while training programmes (own or coach) were important for back, knee and wrist injuries (table 3, online supplemental table S4, figure S3).
Table 3
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Top predictors for injury locations ranked by variable importance metric
Expert model estimates
A subset of variables was selected based on expert feedback and included in logistic regression models to estimate the likelihood of an acute injury sustained during weightlifting for the injury locations. Men were almost two times as likely to sustain injuries for shoulders, back, knees or wrists than women (table 4). Injuries are more likely to occur at younger ages for knees and wrists. Chronic inflammation/osteoarthritis increased the risk at all injury locations. Following their own programme may be associated with shoulder injuries, but this could be confounded with age, since older male weightlifters are more likely to follow their own programme.28 Longer time spent on supplementary exercises were associated with sustaining wrist injuries and longer time to cool-down was associated with an increased risk for shoulder injuries. Concurrent yoga/Pilates lowered the risk of back injuries. Those who believe that following a training-specific nutrition programme was important for their weightlifting training (ie, recovery, muscle increase) were less likely to report a shoulder injury. Following their own programme was associated with knee injuries. Concurrent training in CrossFit was associated with back injuries. However, prior sport participation (body building, power lifting, ball sports, gymnastics) was not associated with an injury risk sustained during weightlifting.
Table 4
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ORs and 95% CIs for predicting the likelihood of a weightlifting injury at different locations
Discussion
A total of 976 respondents from six countries, ages 35–88 years, were included in an analysis to predict acute injuries sustained during weightlifting that restrict training. The main findings were as follows: (1) men had a higher prevalence of weightlifting injuries than women; (2) chronic inflammation or osteoarthritis were common among both men and women. This was associated with injuries; (3) training-specific variables, such as choices of training programmes or nutrition programmes may aid in preventing injuries.
Sport injuries in older athletes
Self-reported locations for acute weightlifting injuries that affected training were shoulders, back, hips, knees and wrists with a prevalence from 13% to 35% during their weightlifting careers in this study cohort. Shoulders, knees, hips and lower back were also the most reported injury locations for weightlifting or powerlifting.15 20 29 In Swedish subelite powerlifters, ages 18 and above, 20%–40% experienced injuries in the prior year. However, while injuries affected the training practice, these did not prevent the athletes from training or competing.20
Injuries in older athletes are less well studied.13 30 While physiological function and sports performance declines with advancing age,31 competitive Masters are examples of resilience and functional capacity,4 but Masters athletes may be at an elevated risk of injury compared with their younger counterparts.32 In elderly male athletes, ages 70–81, the majority (81%) had experienced a sports-related injury in the past 10 years.33 Masters runners at an international competition reported an injury rate of 49% in the previous year with knee injuries accounting for 19%. Furthermore, common medications used in older athletes for short-term symptom relief or for management of chronic conditions may have significant adverse effects on physiological functions.34
Factors related to weightlifting injuries
In this international group of Masters weightlifters, men were almost twice as likely to sustain injuries than women. Sex differences in sport injuries have also been observed in prior studies.35 Chronic inflammation or osteoarthritis was associated with injuries. A longer time for cool-down or supplementary exercises was associated with an increased injury risk. The length of time for specific exercises could be an indicator of overuse, adding more stress to joints after a training session. Older male weightlifters more commonly supplement a programme by their coach with their own programme than younger or female Master weightlifters.28 While in our study following one’s own programme was associated with knee injuries, it is possible that the weightlifters found it necessary to adjust their programme due to pre-existing conditions or lack of access to qualified coaches familiar with the needs of older athletes. Mobility exercises lowered the risk of back injuries consistent with recommendations in other studies.36 Higher training frequency was associated with injuries similar to previous findings for powerlifters20 where overload could be a risk factor or lower training frequency as a consequence of injuries. Nutrition supporting training and recovery may reduce the injury risk. Access to qualified nutrition support has been highlighted for achieving competitive goals, energy and muscle gain or retention.37 Adequate protein intake and optimising nutrition may affect training capacity, muscle mass and reduce inflammatory burden in older athletes.38 While weightlifters often meet protein requirements, women placed more importance on nutrition than men, and older men were less aware of the utility of nutrition for training.28
ML algorithms to predict sports injuries
Multiple factors can influence sports performances requiring coaches, medical professionals and knowledge about nutrition. We explored the application of several ML algorithms to identify potential factors associated with weightlifting injuries in Master athletes. These probabilistic models can use increasing numbers of variables regarding training factors, health conditions and experience with prior sports. The accuracy of ensemble ML methods is highest for back, knee, hips and wrist injuries, 0.727–0.876, and lowest for shoulder injuries, 0.644. This level of performance is similar to ML models in team sports with an accuracy of 0.7039 or 0.75–0.82940 in a systematic review of 11 studies with number of participants ranging from 25 to 363 participants. ML models are only one step in identifying potentially important variables to investigate as risk factors, preventative measures or possible interaction effects. Classic logistic regression models using all variables had similar accuracy as the ML models and could provide further details regarding ORs for a subset of expert-selected predictors.
Study limitations and strengths
Injuries were self-reported in an online survey, and thus may suffer from recall bias. Injuries were defined as acute injuries sustained during weightlifting resulting in training restrictions. This does not address whether an injury required medical attention or led to training interruptions for any length of time. This is both a limitation and a strength, since there is no indication about severity of injuries or current prevalence, but it captures health restrictions more broadly in this population. The survey was given in June 2021, over a year since the start of the COVID-19 pandemic, and thus it was not possible to ask about injuries in the year prior, since athletes may have trained less or found new ways of physical activities due to closures of training facilities or cancellation of competitions. Causality between training practices and injury occurrence cannot be established since information about timing of the injuries was not available. Training practices could be risk factors for injuries, or practices may change as a consequence of injuries. Sport history and prior injuries as well as participation in other sports in addition to weightlifting could have an influence on injuries occurring during weightlifting. Chronic inflammation or osteoarthritis was self-reported, and thus does not meet the rigour of medical diagnoses. However, if the answer was affirmative to the question about presence of chronic inflammation, respondents were asked to specify, and thus more detailed information was available for data quality checks.
Implications
It is of note that Master weightlifters continue training despite health challenges due to injuries that could be minor. Commonly reported injury locations with prevalence 13%–35% were shoulders, knees, back, hips and wrists. Men were at higher risk of experiencing injuries at all injury locations, except hips. Athletes, coaches and health professionals should be aware of the high prevalence of chronic inflammation or osteoarthritis that restricts weightlifting training of Master athletes; thus, athletes should be screened for osteoarthritis and the training programme should be adjusted accordingly to avoid worsening of this condition or future sports injuries. Several training-related factors were identified as potentially associated with injury locations. A combination of factors rather than single factors may contribute to the risk of injuries and a holistic approach to athletes’ health is needed. Modifiable factors for this population were training frequency and nutrition. Designing their own programme, a longer time on cool-down or supplementary exercises, or disregarding nutrition, were associated with increased risk of injury. It can be speculated that following one’s own training programme may be necessary to modify exercises to fit their functional capacity. Longer cool-down time may be a proxy for adding more exercises at the end of a possibly strenuous training unit. Thus, training exercises and times scheduled for these should be carefully considered in a weightlifting training programme. Further prospective cohort studies with detailed training and nutrition diaries are needed to investigate effective preventative strategies for weightlifting injuries.
To our knowledge, this work represents one of the first direct comparisons of several probabilistic and deterministic prediction methods for injuries in an individual sport. Our results are encouraging for more widespread adoption of data-driven probabilistic risk-monitoring tools in Masters sports.
Contributors: MH conceptualised the study and reviewed the literature. MH is the guarantor of the study. Both authors performed statistical analyses and wrote the manuscript.
Funding: The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests: None declared.
Patient and public involvement: Active weightlifters provided feedback on the survey questions.
Provenance and peer review: Not commissioned; externally peer reviewed.
Supplemental material: This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.
Data availability statement
Data are available in a public, open access repository. Reference: Huebner, Marianne (2022), Weightlifting Injuries in Master Athletes, Dryad Digital Repository, Dataset, https://doi.org/10.5061/dryad.51c59zwb3.
Ethics statements
Patient consent for publication:
Consent obtained directly from patient(s)
Ethics approval:
This study involves human participants but the study protocol was approved by the Michigan State University Human Research Ethics Committee and all participants provided online informed consent (STUDY00006179) exempted this study. Participants gave informed consent to participate in the study before taking part.
Acknowledgements
Expert coaches and athletes provided feedback on the variables in this dataset that are potentially associated with weightlifting injuries. Joelle Emery, President Michigan Weightlifting Federation; Daniela Jantzen, Germany, National Masters Chair; Jodi Stumbo, USA, National Masters Hall of Fame; Michael Cohen, USA, National Masters Chair; Mark Gomes, Canada, President, and National Masters Chair; Fred Lowe, 3 times Olympian. The results of this study do not constitute endorsement by these individuals.
Jenkin CR, Eime RM, Westerbeek H, et al. Sport and ageing: a systematic review of the determinants and trends of participation in sport for older adults. BMC Public Health2017; 17. doi:10.1186/s12889-017-4970-8•Google Scholar•PubMed
Langhammer B, Bergland A, Rydwik E, et al. The importance of physical activity exercise among older people. Biomed Res Int2018; 2018:1–3. doi:10.1155/2018/7856823•Google Scholar•PubMed
Dionigi RA. The competitive older athlete: a review of psychosocial and sociological issues. Topics in Geriatric Rehabilitation2016; 32:55–62. Google Scholar
Huebner M, Arrow H, Garinther A, et al. How heavy lifting lightens our lives: content analysis of perceived outcomes of masters weightlifting. Front Sports Act Living2022; 4:778491. doi:10.3389/fspor.2022.778491•Google Scholar•PubMed
Huebner M, Ma W, Rieger T, et al. Weightlifting during the COVID-19 Pandemic-A transnational study regarding motivation, barriers, and coping of master athletes. Int J Environ Res Public Health2021; 18. doi:10.3390/ijerph18179343•Google Scholar•PubMed
Eime RM, Young JA, Harvey JT, et al. A systematic review of the psychological and social benefits of participation in sport for adults: informing development of a conceptual model of health through sport. Int J Behav Nutr Phys Act2013; 10:135. doi:10.1186/1479-5868-10-135•Google Scholar•PubMed
Pons-Villanueva J, Seguí-Gómez M, Martínez-González MA, et al. Risk of injury according to participation in specific physical activities: a 6-year follow-up of 14 356 participants of the sun cohort. Int J Epidemiol2010; 39:580–7. doi:10.1093/ije/dyp319•Google Scholar•PubMed
Choe J-P, Kim J-S, Park J-H, et al. When do individuals get more injured? relationship between physical activity intensity, duration, participation mode, and injury. Int J Environ Res Public Health2021; 18. doi:10.3390/ijerph182010855•Google Scholar•PubMed
Tayrose GA, Beutel BG, Cardone DA, et al. The masters athlete: a review of current exercise and treatment recommendations. Sports Health2015; 7:270–6. doi:10.1177/1941738114548999•Google Scholar•PubMed
Kerr ZY, Collins CL, Comstock RD, et al. Epidemiology of weight training-related injuries presenting to United States emergency departments, 1990 to 2007. Am J Sports Med2010; 38:765–71. doi:10.1177/0363546509351560•Google Scholar•PubMed
Lauersen JB, Bertelsen DM, Andersen LB, et al. The effectiveness of exercise interventions to prevent sports injuries: a systematic review and meta-analysis of randomised controlled trials. Br J Sports Med2014; 48:871–7. doi:10.1136/bjsports-2013-092538•Google Scholar•PubMed
Strömbäck E, Aasa U, Gilenstam K, et al. Prevalence and consequences of injuries in Powerlifting: a cross-sectional study. Orthop J Sports Med2018; 6:232596711877101. doi:10.1177/2325967118771016•Google Scholar•PubMed
Baker BD, Lapierre SS, Tanaka H, et al. Role of Cross-training in orthopaedic injuries and healthcare burden in masters swimmers. Int J Sports Med2019; 40:52–6. doi:10.1055/a-0759-2063•Google Scholar•PubMed
Huebner M. Dataset: Weightlifting injuries in master athletes. Dryad Digital Repository2022; Google Scholar
Hastie T, Tibshirani R, Friedman J, et al. The elements of statistical learning: data mining, inference, and prediction. Springer-Verlag2001; Google Scholar
Liu Y, Chen P-HC, Krause J, et al. How to read articles that use machine learning: users' guides to the medical literature. JAMA2019; 322:1806–16. doi:10.1001/jama.2019.16489•Google Scholar•PubMed
R Core Team. R: a language and environment for statistical computing. Vienna, Austria, R Foundation for Statistical Computing2021; Google Scholar
Huebner M, Faber F, Currie K, et al. How do master Weightlifters train? A transnational study of Weightlifting training practices and concurrent training. Int J Environ Res Public Health2022; 19. doi:10.3390/ijerph19052708•Google Scholar•PubMed
Patelia S, Stone RC, El-Bakri R, et al. Masters or pawns? examining injury and chronic disease in male masters athletes and chess players compared to population norms from the Canadian community health survey. Eur Rev Aging Phys Act2018; 15:15. doi:10.1186/s11556-018-0204-z•Google Scholar•PubMed
Huebner M, Meltzer DE, Perperoglou A, et al. Age-Associated performance decline and sex differences in Olympic Weightlifting. Med Sci Sports Exerc2019; 51:2302–8. doi:10.1249/MSS.0000000000002037•Google Scholar•PubMed
Opar D, Drezner J, Shield A, et al. Acute injuries in track and field athletes: a 3-year observational study at the Penn relays carnival with epidemiology and medical coverage implications. Am J Sports Med2015; 43:816–22. doi:10.1177/0363546514562553•Google Scholar•PubMed
Bueno AM, Pilgaard M, Hulme A, et al. Injury prevalence across sports: a descriptive analysis on a representative sample of the Danish population. Inj Epidemiol2018; 5:6. doi:10.1186/s40621-018-0136-0•Google Scholar•PubMed
Close GL, Sale C, Baar K, et al. Nutrition for the prevention and treatment of injuries in track and field athletes. Int J Sport Nutr Exerc Metab2019; 29:189–97. doi:10.1123/ijsnem.2018-0290•Google Scholar•PubMed
Van Eetvelde H, Mendonça LD, Ley C, et al. Machine learning methods in sport injury prediction and prevention: a systematic review. J Exp Orthop2021; 8:27. doi:10.1186/s40634-021-00346-x•Google Scholar•PubMed