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Original research
Impact of physical exercise intervention and PPARγ genetic polymorphisms on cardio-metabolic parameters among a Chinese youth population
  1. Juan Su1,
  2. Hui Wang2,
  3. Yuanrui Tian2,
  4. Haixu Hu1,
  5. Wanjian Gu3,
  6. Ting Zhang2,
  7. Mengxia Li2,
  8. Chong Shen2,
  9. Harvest F Gu4
  1. 1Department of Physical Education, Nanjing University of Aeronautics and Astronautics, Nanjing, China
  2. 2Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China
  3. 3Department of Clinical Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China
  4. 4Center for Pathophysiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China
  1. Correspondence to Dr Chong Shen; sc100{at}126.com; Dr Harvest F Gu; feng.gu{at}cpu.edu.cn

Abstract

Objective Physical inactivity inChinese youth students particularly in senior high schools, who participate inthe National Higher Education Entrance Examination (NCEE) is very common. Inorder to explore the beneficial effects from physical exercise and education afterNCEE, we performed a Physicalexercise Intervention Program in the Youth (PiPy) to evaluate the interaction with PPARγ genetic variants on cardiovascular and metabolicparameters.

Methods A total of 772 freshmen (males 610/females162) from high schools to university were recruited into the PiPy cohort, which was designedaccording to the National Student Health Standards in China. Anthropometric data were collected, whilephysical activities and body composition at the baseline of PiPy cohort weremeasured with SECAprotocols. Eighttagged single nucleotide polymorphisms (SNPs) in the PPARγ gene were genotyped with TaqMan allelicdiscrimination.

Results After physical exercise intervention forthree months, in parallel with increased physical activities, BMI and skeletalmuscle content in all subjects was enhanced, while heart rate and bloodpressures were decreased. Furthermore, SNPs in 5’-UTR of the PPARγ gene, including rs2920502,rs9817428 and rs2972164, were found to be associated with the changes of BMI.Body weight in the subjects with BMI <18.5and 18.5-23.9 kg/m2 were increased,while the obese subjects (BMI ≥24.0 kg/m2) decreased.

Conclusion The present study for the first timedemonstrated that the PiPy could improve cardio-metabolic parameters such asheart rate, blood pressures and BMI for Chinese youth students after NCEE, inwhich the genetic interactive effects of PPARγ should be included into obesityintervention.

  • genetics
  • obesity
  • public health
  • university
  • exercise
http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjsem-2019-000681

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    Footnotes

    • Contributors HFG proposed, and CS, JS and HFG designed the study. JS, HH and WG collected anthropometric data. HW and YT performed genotyping experiments. HFG, CS, HW, JS and HH interpreted data. HFG, SC and HW prepared the manuscript. All authors take responsibility for the integrity of data and accuracy of data analysis and have approved the final version of manuscript

    • Funding This study was supported by the research grant from Nanjing University of Aeronautics and Astronautics (NUAA-160830), Jiangsu Provincial Fourth “333 Project”, the Priority Academic Programme for the Development of Jiangsu Higher Education Institutions (Public Health and Preventive Medicine) and the start grant of China Pharmaceutical University (CPU-180517).

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Ethics approval The ethics approval of the present study was obtained from Research Ethics Committee in Nanjing Medical University, China (No. 2016–290).

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data availability statement Data are available upon reasonable request. All data relevant to the study are included in the article or uploaded as supplementary information. Data available as stated above.