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Effect of short moderate intensity exercise bouts on cardiovascular function and maximal oxygen consumption in sedentary older adults
  1. Karani Magutah1,
  2. Kihumbu Thairu2,
  3. Nilesh Patel2
  1. 1Medical Physiology, Moi University School of Medicine, Eldoret, Kenya
  2. 2Medical Physiology, University of Nairobi, Nairobi, Kenya
  1. Correspondence to Dr Karani Magutah; kmagutah{at}yahoo.com

Abstract

Aim To investigate effect of <10 min moderate intensity exercise on cardiovascular function and maximal oxygen consumption (Embedded Image O2max) among sedentary adults.

Methods We studied 53 sedentary urbanites aged ≥50 years, randomised into: (1) male (MS) and (2) female (FS) undertaking three short-duration exercise (5–10 min) daily, and (3) male (ML) and (4) female (FL) exercising 30–60 min 3–5 days weekly. Resting systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate and Embedded Image O2max were measured at baseline and 8 weekly for 24 weeks.

Results At baseline, 50% MS, 61.5% ML, 53.8% FS and 53.8% FL had SBP ≥120 mm Hg, and 14.3% MS, 53.8% ML, 23.1% FS and 38.5% FL had DBP ≥80 mm Hg. At 24 weeks, where SBP remained ≥120 mm Hg, values decreased from 147±19.2 to 132.3±9.6 mm Hg (50% of MS), from 144±12.3 to 128±7.0 mm Hg (23.1% of ML), from 143.1±9.6 to 128.0±7.0 mm Hg (53.8% of FS) and from 152.3±23.7 to 129±3.7 mm Hg (30.8% of FL). For DBP ≥80 mm Hg, MS and FS percentages maintained, but values decreased from 101±15.6 to 84.5±0.7 mm Hg (MS) and 99.0±3.6 to 87.7±4.9 mm Hg (FS). In ML and FL, percentage with DBP ≥80 mm Hg dropped to 15.4% (86.1±6.5 to 82.5±3.5 mm Hg) and (91.4±5.3 to 83.5±0.71 mm Hg). Embedded Image O2max increased from 26.1±4.4 to 32.0±6.2 for MS, from 25.8±5.1 to 28.8±5.4 for ML (group differences p=0.02), from 20.2±1.8 to 22.7±2.0 for FS and from 21.2±1.9 to 24.2±2.7 for FL (groups differences p=0.38).

Conclusion Accumulated moderate intensity exercise bouts of <10 min confer similar-to-better cardiovascular and Embedded Image O2max improvements compared with current recommendations among sedentary adults.

  • cardiovascular function
  • maximal oxygen consumption
  • short and long moderate intensity exercise sessions
  • sedentary
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What are the new findings?

  • Performing three bouts of moderate intensity exercise each lasting 5–10 min daily yields similar-to-better maximal oxygen consumption (Embedded Image O2max) in sedentary adults compared with current WHO recommendations.

  • Accumulating moderate intensity exercise regardless of bout length improves cardiovascular functions of blood pressure and heart rate in both males and females.

Introduction

Recent revision of blood pressure (BP) guidelines has increased the percentage of people in the high BP and hypertension category.1 2 This comes at a time of rising shift in lifestyles where, for example, in Eldoret, Kenya, our study setting, 82% of the elderly persons do not participate in regular exercise or physical activity (PA) that would result in energy expenditure ≥1.5 metabolic equivalent (MET) minutes, and are therefore sedentary.3 4 Those in high BP categories also form most of those reported in the current rise in sedentary-related health problems in sub-Saharan Africa.5–8 At a time when health benefits of exercise are being widely promoted,9 the reason for decrease in PA, a modifiable risk factor and with it accompanying cardiovascular health problems, is not clear. It is known that high peak maximal oxygen consumption (Embedded Image O2max) from increased leisure time PA is correlated with reduced cardiovascular morbidity and mortality.10 Thus, there is a need to change how existing recommendations are promoted, or to develop exercise options which yield similar cardiorespiratory fitness and encourage exercise involvement.

There are many approaches to improve adherence and compliance of PA that have been tested. One approach is the use of shorter exercise sessions,11 but its adoption is hindered by lack of sufficient supporting data. Opinions differ on the benefits of short exercise bouts,11–17 and a different approach in regime, population or setting that addresses the lack of PA/exercise could be useful. In a previous study involving the same population as in this study, we found that shorter exercise sessions are beneficial in improving cardiometabolic markers and body composition.18 19 However, the few studies that have tested the effect of supervised exercise bouts on cardiac performance among the elderly have shown conflicting results.20–22 Therefore, further studies especially among the lesser studied older sedentary black adults are needed as this group shows >90% likelihood of developing hypertension in their lifetimes even when their mid-life BP are normal,23 24 under the previous BP categorisation that had a higher cut-off point for normal ranges. Thus, in this study, we investigated the effect of moderate intensity jogging bouts lasting <10 min on BP, pulse pressure (PP) and heart rate (HR) and Embedded Image O2max among sedentary black adults who had a weekly MET minutes <600 min.9 25 The study involved <10 min bouts in cumulative weekly minutes that matched the current WHO exercise prescription9 of 3–5 weekly sessions each lasting ≥30 min.

Materials and methods

Following a local print advertisement and using the WHO Global Physical Activity Questionnaire (GPAQ),25 between September 2016 and May 2017, we recruited 53 (27 males; 26 females) healthy sedentary volunteers aged ≥50 years from Eldoret, Kenya into this randomised controlled field trial. Eligibility for inclusion based on absence of physical injuries, cardiovascular disease (BP screening done at recruitment) or any recent treatment for cardiovascular disease. Hypertensive volunteers were immediately referred for pharmacotherapy. Measurements of BP, HR and estimate Embedded Image O2max were done at the start and at 8 weekly intervals over the course of the study. The shuttle run test (SRT) was used for Embedded Image O2max estimation and for continuous cardiovascular assessment during exertion. SRT is a multistage test of cardiovascular fitness and Embedded Image O2max estimation that incorporates the exercise intensity. This provided the effectiveness of the two different exercise prescriptions. For reproducibility, the same researcher performed all the measurements using the same equipment, protocols, subject posture and time-of-day throughout the 24 weeks of study duration.

Randomisation was done at individual level based on gender and exercise regime, placing participants into four groups: group 1 (male, MS) and group 2 (female, FS) short-duration exercise bouts, and group 3 (male, ML) and group 4 (female, FL) long-duration exercise bouts. The MS and FS undertook 5–10 min of moderate intensity jogging thrice daily. The ML and FL undertook the same intensity jogging for 30–60 min 3–5 days per week. All participants kept their own exercise log and wore Polar Wearlink Actitrainer Accelerometers (ActiGraph, Pensacola, Florida, USA) on selected days to assess their adherence to their respective exercise protocol. Exercise logs and accelerometer data were analysed weekly to check if participants had equivalent cumulative exercise durations and MET-minutes.

Data were collected at the start and at 8-week intervals over 24 weeks. For baseline data, participants’ biodemographic characteristics, PA and exercise patterns were recorded. Pre-exertion BP was taken as the average of two measurements taken 2 min apart using an electronic sphygmomanometer after 5 min of rest in a sitting position. PP was determined by getting the difference between the resultant systolic (SBP) and diastolic (DBP) pressures. HR was measured with a polar HR monitor at the start and continuously during the incremental change in speed of the 20 m SRT up to the point of completion of the test or discontinuation as per the test guidelines. Estimation of Embedded Image O2max was done by application of the Ramsbottom beep score calculator,26 based on the level of the SRT achieved by the participants. Measurements of HR and BP were also taken after 5 min of recovery following completion of the SRT. Thereafter, and for a period of 8 weeks before the next data collection point, participants followed the exercise prescribed for their group by jogging that raised their HR to 50%–70% of their maximal expected HR computed as 220−age in years, one of the criteria for determining moderate intensity exercise. On days when they did not wear accelerometers, this was ascertained by a jog where they could talk but not sing, the accepted alternative where objective monitoring lacks.27 Follow-up of participants was done by reminders through phone calls and direct meeting every week. Analysis of completed GPAQs was done every week to check that participants adhered to their exercise prescriptions and that the cumulative exercise times were similar in both groups and for each of the 24 weeks of the protocol. Thus, none of the regimes had a greater improvement than the other and therefore all adhering participants per regime were retained in the study.

STATA V.13 was used for data analysis. Data were presented as mean and SD. Repeated measures analysis of variance was used for analysis of data between the exercise regime groups for each sex over the 24 weeks. A value of p<0.05 was considered as statistically significant.

Results

Mean age for males and females was 55.5±3.0 and 53.9±3.0 years, respectively. All participants had secondary school-level education and 88.4% of males and 71.4% of females had university/college education. Ninety-one percentage of participants were currently working in white collar jobs and 9% had retired from it.

Baseline data showed that 22.2% of males and 23.1% of females had pre-SRT BP ≥140/90 mm Hg. Those with SBP >140 mm Hg but DBP<90 mm Hg were 14.8% and 15.4% for males and females, respectively. Only one male and one female had DBP ≥90 mm Hg and SBP <140 mm Hg. After SRT at the start, the pre-exercise BP and 5 min postexercise BP were not different between the participants (SBP: p=0.12 and p=0.26 and DBP: p=0.83 and p=0.32 for males and females, respectively).

Using the lowest cut-offs as per the new BP guidelines for elevated and hypertensive BP,1 2 50% of MS (SBP 147.0±19.2 mm Hg), 61.5% of ML (SBP 144.0±12.3 mm Hg), 53.8% of FS (SBP 143.1±9.6 mm Hg) and 53.8% of FL (SBP 152.3±23.7 mm Hg) had resting SBP ≥120 mm Hg at the start. Using the same guidelines, 14.3% of MS DBP (101.0±15.6 mm Hg), 53.8% of ML (DBP 86.1±6.5 mm Hg), 23.1% of FS (DBP 99.0±3.6 mm Hg) and 38.5% of FL (DBP 91.4+5.3 mm Hg) had DBP ≥80 mm Hg. Similarly, all groups had Embedded Image O2max lower than expected for their ages. Based on existing categorisations for gender and age, MS, ML and FS groups had ‘very poor’ levels of Embedded Image O2max with the FL group in the ‘poor’ category.28 Accelerometry data showed weekly cumulative exercise minutes to be similar for MS and ML (161.8±7.2 vs 162.6±6.1), and also for FS and FL (158.3±3.6 vs 156.1±2.7, respectively). Adherence over the 24 weeks regime was 100% for MS (n=14) and FS (n=13), and 61.5% and 76.9% for ML (n=14) and FL (n=13), respectively. These baseline demographic and clinical parameters are shown in table 1.

Table 1

Baseline demographic and clinical characteristics of the participants

At the 24th week, although 50% of MS group had SBP ≥120 mm Hg, their mean SBP decreased from 147±19.2 mm Hg to 132.3±9.6 mm Hg. In the ML group, the percentage with SBP ≥120 mm Hg dropped from 61.5% to 23.1% (144±12.3 mm Hg to 128±7.0 mm Hg). Although the percentage with SBP ≥120 mm Hg in FS group did not change, the mean values decreased from 143.1±9.6 mm Hg to 128.0±7.0 mm Hg. In the FL group, the percentage with SBP ≥120 mm Hg dropped from 53.8% to 30.8% (152.3±23.7 mm Hg to 129±3.7 mm Hg). For those with DBP ≥80 mm Hg, there was no percentage change in either the MS or FS groups, but their mean values dropped from 101±15.6 mm Hg to 84.5±0.7 mm Hg and from 99.0±3.6 mm Hg to 87.7±4.9 mm Hg, respectively. For the ML group, the percentage with DBP ≥80 mm Hg dropped from 53.8% to 15.4% (86.1±6.5 mm Hg to 82.5±3.5 mm Hg), and from 38.5% to 15.4% in the FL group (91.4±5.3 mm Hg to 83.5±0.71 mm Hg). Pooling data from all participants, we similarly observed a mixed decrease in BP and HR in the two exercise groups. Resting SBP in ML, resting DBP in MS as well as DBP at 5 min in MS all reduced significantly (p<0.05). These significant declines however showed no difference in the manner of the change between regimes (all p≥0.05) (table 2). Comparison of changes in different variables between study groups showed no significant gender differences. Associated PP changes over the study period are shown in table 3. Except for PP decay at exhaustion among males, there was no differences between the exercise groups. This was despite ML resting PP and FS exhaustion PP showing significant improvement over the 24 weeks compared with respective opposite regimes. For the two regimes, the pre-SRT and 5 min post-SRT BP differences were the same (SBP: p=0.42 and p=0.24 and DBP: p=0.83 and p=0.32, for males and females, respectively).

Table 2

Absolute blood pressure, heart rate and V·Embedded ImageO2max changes

Table 3

Pulse pressure changes over 24 weeks of the study period

The Embedded Image O2max across all groups rose from baseline to the 24th week (figure 1), but there was no significant difference between the groups of the same sex at each of the four data collection points (p≥0.05) for the different exercise regimes. The mean change in Embedded Image O2max at the start and 24th week were however different among males (p=0.02) but not females (figure 2).

Figure 1

Embedded Image O2max from week 1 to week 24. MS, short exercise bouts male; ML, long exercise bouts male; FS, short exercise bouts female; FL, long exercise bouts female.

Figure 2

Mean change in Embedded Image O2max between the 1st and 24th week. Short, short exercise bouts; long, long exercise bouts. P=0.02 denotes significant difference between short and long exercise bouts among males.

Discussion

Baseline results

At the start of the study, the participants’ mean pre-exertion SBP and DBP were in the stage 1 hypertension category based on the current BP guidelines,1 2 that is, between 130–139 SBP and 80–89 DBP mm Hg. Thus, a majority of participants had hypertensive tendency at recruitment. Their SBP rise and DBP decay at exhaustion from SRT, and return to pre-exertion values within 5 min of rest was within previously reported data.29 That the 5 min post-SRT BP was similar to the BP before the run test demonstrated good normalisation. However, as nearly a quarter had pre-exertion BP ≥140/90, and, based on the WHO and the criterion by Alberti et al for including SBP ≥130 mm Hg or DBP ≥85 mm Hg in metabolic syndrome diagnosis,30 31 and, further, given the new published guidelines,1 2 a significant proportion of our participants appeared at risk to developing metabolic syndrome at the start. Similarly, based on the published reference Embedded Image O2max values,28 the Embedded Image O2max means for males and females at the start were below that for their ages, demonstrating a reduced cardiorespiratory health probably related or due to their sedentary lifestyle. With advancing age and adoption of sedentary lifestyles, the low Embedded Image O2max and elevated BP pose higher risk for cardiovascular disease.1 2 22 32 33

Cardiovascular effects at end point

All the participants in the different exercise groups showed mixed decrease in BP and HR over the 24-week exercise period. The BP and HR levels before the SRT, at exhaustion from the SRT and at 5 min after SRT appeared to decline over the study period. Among ML, resting SBP, resting DBP and DBP at 5 min all showed significant drop at week 24 when compared with respective baseline values. What was novel is that the mean change difference between week 24 and baseline was similar for the two regimes. While exercise has been shown to improve cardiovascular performance, thus reducing cardiovascular mortality and morbidity among the elderly through reduction of fatty deposits in small blood vessel walls that cause blockage and/or reduced elasticity thus raising BP,34–38 our findings show that short exercise bouts were as effective in reducing BP and HR as the currently recommended longer exercise bouts,9 although the follow-up period probably needed lengthening to demonstrate significant changes in more variables. Until recently, when Landram et al39 demonstrated that intermittent bouts of <10 min had comparable BP outcomes as the recommended exercise regime,39 not much was known of what effect <30 min exercise bouts would have on cardiovascular parameters. In that study, unlike this study, the age range was broader, and the rest interval between the short exercise bouts was 10 min. Another study40 used longer exercise bouts of 15 min, but we found a similar reduction in BP and HR using shorter bouts.

After each SRT, no difference was found in HR recovery to the pre-SRT levels in the different exercise groups over the 24-week study period. Furthermore, in all exercise groups, HR both before SRT and after the 5 min post-SRT rest period was lower at the end of 24th week compared with the start. Additionally, the HR recovery following SRT at 24th week was similar for the two regimes. The similarity in the HR recovery after SRT at the end of the study underscores the similarity of effects of intermittent exercise regime tested in this study. This shows that the shorter bouts could be as effective in producing the benefits associated with faster and near complete HR recovery for better cardiovascular health,41 42 as is seen with the traditional (longer bout) regimes.

PP is an accepted indicator of cardiovascular mortality and morbidity with lower values being protective.43–45 In our study, resting PP dropped over 24 weeks in both males and females for both exercise regimes, but, except in exhaustion PP where mean change was higher in MS compared with ML, there was no difference in the mean change between regimes. Start to end point data showed significant drops only in resting PP among ML and exhaustion PP among FL, but the study had primarily sought to test for differences in the mean change over the study period between the regimes, which was found to be largely similar. This mix of results suggest that none of the regimes is superior. Recent studies have shown workouts lasting >45 min for a period of 8 weeks duration reduce PP,46 and our study shows that exercise bouts lasting <10 min, performed regularly, are also effective in reducing the PP. However, the proposed threshold for improved PP, that is, <76 mm Hg,44 45 was not achieved in this study, and probably a longer period of exercise may further improve PP.

The similarity of change in SBP, DBP, HR and PP in all the groups shows that in this population, short exercise bouts are as effective as the longer ones in improving these parameters. Based on this finding, the short exercise bouts could be used for individuals of similar demographics.

Embedded ImageO2max effects at end point

In line with the reported increase in Embedded Image O2max with moderate intensity exercise,47–49Embedded Image O2max appeared to increase in both males and females over the 24 weeks study period, and probably a longer follow-up may probably have yielded more significant changes. There however was a significant difference in the manner of Embedded Image O2max change for males but not for the females. Males in the accumulated shorter exercise bouts showed higher Embedded Image O2max compared with those on the longer exercise bouts. It has been demonstrated that short exercise bouts may be better in improving Embedded Image O2max.40

As the rate of increase of Embedded Image O2max over the 24 weeks showed either no difference between the short or long exercise bouts in the females, or, that indeed short bouts were better for males suggests that the effect of accumulated short bouts exercise on Embedded Image O2max is at least similar to, if not better than the currently recommended exercise bouts lasting ≥30 min. Similar results have been reported in a short 4-week study where individuals with cumulatively similar weekly exercise time with exercise regimes of 10 and 30 min per session, showed no difference in Embedded Image O2max change.39 Our findings add to the growing evidence that intermittent exercise programme performed so that the cumulative exercise time matches the current recommended exercise regime is at least as effective as the existing recommendation of 150 weekly minutes of moderate intensity exercise done in 3–5 weekly sessions of 30–60 min each,9 in increasing Embedded Image O2max among the elderly.

However, none of the exercise regimes used in this study helped participants achieve Embedded Image O2max levels for their age. While there was improvement for all groups, the Embedded Image O2max values remained below the proposed levels that correspond to better Cardiorespiratory fitness outcomes. In fact, across all our groups, the improvement over the 24-week period was marginal, rising from the very poor and poor categories to at the most fair category as compared with the Physical Fitness Certification Manual28 information. A longer exercise periods may yield better improvements for this age bracket whose bodies may take longer to adjust and who have higher loss in aerobic power,50 compared with the younger populations.

Limitations

Participants self-selected themselves for this study in response to a local print advert. This could have affected the representativeness of results in that the recruitment criteria were biased towards those who saw the print advert only. Additionally, as it was impossible to include blinding in the study protocol, the investigators and the participants all knew who was on which exercise regime. This may have affected adherence from peer influences. Furthermore, dietary habits, use of stimulants like caffeine and participants’ renal status, all known confounders in cardiovascular and Embedded Image O2max measurements were not considered during the follow-up and the data analysis. That we used indirect methods for Embedded Image O2max estimation may also have affected our results. These confounders may affect the generalisability of our results.

Strengths

Our study showed that in both elderly males and females, moderate intensity exercise bouts lasting <10 min three times a day for 24 weeks improved BP, HR and Embedded Image O2max, and improvement was comparable to exercise bouts of ≥30 min as currently administered in 3–5 days a week. As adherence to exercise is a major factor in regular exercise, our findings could be of benefit to older men and women who face challenge of finding time for long continuous exercise sessions yet seek to improve their maximal oxygen uptake and cardiovascular parameters, improving their health.

Conclusions

For sedentary individuals aged ≥50 years, moderate intensity exercise done in three intermittent daily sessions of <10 min each is as effective in the regulation of BP and improvement of maximal oxygen consumption as the currently recommended regime of 3–5 weekly exercise sessions of similar intensity lasting ≥30 min each.

References

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Footnotes

  • Twitter @karaniMaguth

  • Contributors KM helped in designing protocol, data collection, analysis and writing of the manuscript. Both KT and NT helped with designing of protocol and writing the manuscript.

  • Funding This research was supported by the Consortium for Advanced Research Training in Africa (CARTA). CARTA is jointly led by the African Population and Health Research Center (APHRC) and the University of the Witwatersrand and funded by the Wellcome Trust (UK) (Grant No: 087547/Z/08/Z), the Department for International Development (DfID) under the Development Partnerships in Higher Education (DelPHE), the Carnegie Corporation of New York (Grant No: B 8606), the Ford Foundation (Grant No: 1100–0399), Google.Org (Grant No: 191994), Sida (Grant No: 54100029), MacArthur Foundation (Grant No: 10-95915-000-INP) and British Council.

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were involved in the design, conduct, reporting or dissemination plans of this research. Refer to the 'Materials and methods' section for further details.

  • Patient consent for publication Not required.

  • Ethics approval Study approval was granted by Moi Teaching and Referral Hospital/Moi University institutional research board.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available on reasonable request.

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