Article Text
Abstract
Background High-sensitivity C reactive protein (hs-CRP) is a reliable indicator of atherosclerotic diseases and is associated with hyperinsulinaemia. The purpose of this study is to examine the association between hs-CRP and fasting insulin levels in Korean adults not taking medication for hypertension, dyslipidaemia or diabetes, nor provided with specific dietary advice.
Methods This cross-sectional study included 2588 subjects who participated in the 2015 Korean National Health and Nutrition Examination Survey. High-risk hs-CRP was defined as hs-CRP>2 mg/L. Subjects were divided into four groups with fasting insulin (<5, 5–10, 10–15,>15 uIU/mL)
Results The mean hs-CRP in our sample was 1.22 mg/L. hs-CRP was positively associated with fasting insulin level. The occurrence of high-risk hs-CRP with increasing fasting insulin levels was 7.6%, 9.8%, 19.1% and 28.2%, respectively. In comparing high-risk hs-CRP between the highest (>15 µIU/mL) and lowest (<5 µIU/mL) insulin groups, the OR (95% CI) was 4.59 (2.77–7.58). triglycerides/high-density lipoprotein ratio was also associated with hs-CRP. Low-density lipoprotein cholesterol was not associated with hs-CRP.
Conclusions Higher level of fasting insulin is positively associated with high-risk hs-CRP.
- Heart disease
- Risk factor
- Diabetes
- Carbohydrates
- Cholesterol
- hs-CRP
- Insulin
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Footnotes
Competing interests None declared.
Ethics approval This investigation was conducted according to the principles expressed in the Declaration of Helsinki. The participants of Korean National Health and Nutrition Examination Survey (KNHANES) engaged voluntarily. The KNHANES has been performed since 1998 and received ethical approval by Institutional Review Board of Korea Center for Disease Control and Prevention.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement The entire data can be downloaded from "https://knhanes.cdc.go.kr".