In vivo measurements of muscle specific tension in adults and children

TD O'Brien, ND Reeves, V Baltzopoulos… - Experimental …, 2010 - Wiley Online Library
To better understand the effects of pubertal maturation on the contractile properties of
skeletal muscle in vivo, the present study investigated whether there are any differences in …

[HTML][HTML] Human skeletal muscle possesses an epigenetic memory of hypertrophy

RA Seaborne, J Strauss, M Cocks, S Shepherd… - Scientific reports, 2018 - nature.com
It is unknown if adult human skeletal muscle has an epigenetic memory of earlier encounters
with growth. We report, for the first time in humans, genome-wide DNA methylation (850,000 …

Mechanical properties of the patellar tendon in adults and children

TD O'Brien, ND Reeves, V Baltzopoulos… - Journal of …, 2010 - Elsevier
It is not currently known how the mechanical properties of human tendons change with
maturation in the two sexes. To address this, the stiffness and Young's modulus of the …

[HTML][HTML] Stretching interventions in children with cerebral palsy: why are they ineffective in improving muscle function and how can we better their outcome?

BM Kalkman, L Bar-On, TD O'Brien… - Frontiers in …, 2020 - frontiersin.org
Hyper-resistance at the joint is one of the most common symptoms in children with cerebral
palsy (CP). Alterations to the structure and mechanical properties of the musculoskeletal …

Muscle–tendon structure and dimensions in adults and children

TD O'Brien, ND Reeves, V Baltzopoulos… - Journal of …, 2010 - Wiley Online Library
Muscle performance is closely related to the architecture and dimensions of the muscle–
tendon unit and the effect of maturation on these architectural characteristics in humans is …

Strong relationships exist between muscle volume, joint power and whole‐body external mechanical power in adults and children

TD O'Brien, ND Reeves, V Baltzopoulos… - Experimental …, 2009 - Wiley Online Library
The present study investigated whether differences between adults and children in
mechanical power during single‐joint knee extension tasks and the complex multijoint task …

Systematic review of physical activity and exercise interventions to improve health, fitness and well-being of children and young people who use wheelchairs

TD O'Brien, J Noyes, LH Spencer… - BMJ open sport & …, 2016 - bmjopensem.bmj.com
Aim To perform a systematic review establishing the current evidence base for physical
activity and exercise interventions that promote health, fitness and well-being, rather than …

Tight control of disease activity fails to improve body composition or physical function in rheumatoid arthritis patients

AB Lemmey, TJ Wilkinson, RJ Clayton, F Sheikh… - …, 2016 - academic.oup.com
Objective. RA typically features rheumatoid cachexia [loss of muscle mass (MM) and
excessive total fat mass (TFM), especially trunk FM], which contributes to physical disability …

Association between somatosensory, visual and vestibular contributions to postural control, reactive balance capacity and healthy ageing in older women

L Alcock, TD O'Brien, N Vanicek - Health Care for Women …, 2018 - Taylor & Francis
We investigated the biological systems involved in maintaining equilibrium during unstable
and perturbed conditions in 39 healthy older women and estimated the annual difference in …

Can creatine supplementation improve body composition and objective physical function in rheumatoid arthritis patients? A randomized controlled trial

TJ Wilkinson, AB Lemmey, JG Jones… - Arthritis care & …, 2016 - Wiley Online Library
Objective Rheumatoid cachexia (muscle wasting) in rheumatoid arthritis (RA) patients
contributes to substantial reductions in strength and impaired physical function. The …