Control of the size of the human muscle mass

MJ Rennie, H Wackerhage, EE Spangenburg… - Annu. Rev …, 2004 - annualreviews.org
▪ Abstract This review is divided into two parts, the first dealing with the cell and molecular
biology of muscle in terms of growth and wasting and the second being an account of …

[HTML][HTML] Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise

H Wackerhage, BJ Schoenfeld… - Journal of applied …, 2019 - journals.physiology.org
One of the most striking adaptations to exercise is the skeletal muscle hypertrophy that
occurs in response to resistance exercise. A large body of work shows that a mammalian …

[HTML][HTML] The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis

B Fazzini, T Märkl, C Costas, M Blobner, SJ Schaller… - Critical Care, 2023 - Springer
Background Patients with critical illness can lose more than 15% of muscle mass in one
week, and this can have long-term detrimental effects. However, there is currently no …

Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle

D Cuthbertson, K Smith, J Babraj, G Leese… - The FASEB …, 2005 - Wiley Online Library
The nature of the deficit underlying age‐related muscle wasting remains controversial. To
test whether it could be due to a poor anabolic response to dietary amino acids, we …

Selective activation of AMPK‐PGC‐1α or PKB‐TSC2‐mTOR signaling can explain specific adaptive responses to endurance or resistance training‐like electrical …

PJ Atherton, JA Babraj, K Smith, J Singh… - The FASEB …, 2005 - Wiley Online Library
Endurance training induces a partial fast‐to‐slow muscle phenotype transformation and
mitochondrial biogenesis but no growth. In contrast, resistance training mainly stimulates …

Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle

PL Greenhaff, LG Karagounis… - American Journal …, 2008 - journals.physiology.org
We determined the effects of intravenous infusion of amino acids (AA) at serum insulin of 5,
30, 72, and 167 mU/l on anabolic signaling, expression of ubiquitin-proteasome …

Taurine deficiency as a driver of aging

P Singh, K Gollapalli, S Mangiola, D Schranner… - Science, 2023 - science.org
Aging is associated with changes in circulating levels of various molecules, some of which
remain undefined. We find that concentrations of circulating taurine decline with aging in …

[HTML][HTML] Branched-Chain Amino Acids as Fuels and Anabolic Signals in HumanMuscle

MJ Rennie, J Bohe, K Smith, H Wackerhage… - The Journal of …, 2006 - Elsevier
During exercise, there is an increase in amino acid (AA) oxidation accompanied by a
depression in whole-body protein synthesis and an increase in protein breakdown. Leucine …

The Hippo pathway member Yap plays a key role in influencing fate decisions in muscle satellite cells

RN Judson, AM Tremblay, P Knopp… - Journal of cell …, 2012 - journals.biologists.com
Satellite cells are the resident stem cells of skeletal muscle. Mitotically quiescent in mature
muscle, they can be activated to proliferate and generate myoblasts to supply further …

[HTML][HTML] Metabolite concentration changes in humans after a bout of exercise: a systematic review of exercise metabolomics studies

D Schranner, G Kastenmüller, M Schönfelder… - Sports medicine …, 2020 - Springer
Background Exercise changes the concentrations of many metabolites, which are small
molecules (< 1.5 kDa) metabolized by the reactions of human metabolism. In recent years …