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Exercise-induced phospho-proteins in skeletal muscle

International Journal of Obesity volume 32, pages S18–S23 (2008)Cite this article

Abstract

Efforts to identify exercise-induced signaling events in skeletal muscle have been influenced by ground-breaking discoveries in the insulin action field. Initial discoveries demonstrating that exercise enhances insulin sensitivity raised the possibility that contraction directly modulates insulin receptor signaling events. Although the acute effects of exercise on glucose metabolism are clearly insulin-independent, the canonical insulin signaling cascade has been used as a framework by investigators in an attempt to resolve the mechanisms by which muscle contraction governs glucose metabolism. This review focuses on recent advances in our understanding of exercise-induced signaling pathways governing glucose metabolism in skeletal muscle. Particular emphasis will be placed on the characterization of AS160, a novel Akt substrate that plays a role in the regulation of glucose transport.

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Acknowledgements

This study was supported with funding obtained from Karolinska Institutet, the Swedish Research Council, the Swedish Diabetes Association; the Foundation for Scientific Studies of Diabetology; the Strategic Research Foundation (INGVAR); the Commission of the European Communities (Contract No LSHM-CT-2004-005272 EXGENESIS, Contract No LSHM-CT-2004-512013 EUGENEHEART, and Contract No LSHM-CT-2004-512013 EUGENE2); and an Australian Research Council Discovery Grant (DP0663862).

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Authors and Affiliations

  1. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

    A S Deshmukh & J R Zierath

  2. School of Medical Sciences, RMIT University, Victoria, Australia

    J A Hawley

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  1. A S Deshmukh
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  2. J A Hawley
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  3. J R Zierath
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Correspondence to J R Zierath.

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The authors state no conflict of interest.

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Deshmukh, A., Hawley, J. & Zierath, J. Exercise-induced phospho-proteins in skeletal muscle. Int J Obes 32 (Suppl 4), S18–S23 (2008). https://doi.org/10.1038/ijo.2008.118

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