Stem Cells for the Treatment of Skeletal Muscle Injury
Section snippets
Pathophysiology of skeletal muscle injury
The pathophysiology of skeletal muscle injury is characterized by a sequence of events consisting of degeneration, inflammation, myofiber regeneration, and the formation of fibrotic scar tissue, as described below in detail and illustrated in Fig. 1.
Summary
Among the most commonly prescribed treatments for skeletal muscle injuries are rest, ice application, compression, and elevation as well as heat application and either immobilization or passive range of motion exercises. In many instances, however, these therapies remain suboptimal.
Based on current knowledge, the inflammatory response that follows injury promotes skeletal muscle regeneration, perhaps in part by locally recruiting stem cells through chemotaxis to the zone of injury. Although the
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