Cell Metabolism
Volume 5, Issue 3, 7 March 2007, Pages 161-163
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The Path to Insulin Resistance: Paved with Ceramides?

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Obesity-associated, system-wide elevations in free fatty acids, tumor necrosis factor α, and glucocorticoids increase intracellular lipid metabolites and promote insulin resistance. In this issue, Holland et al. (2007) provide pharmacological and genetic evidence that ceramide plays a key role in the development of insulin resistance induced by these factors.

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