Elsevier

The Lancet

Volume 307, Issue 7961, 27 March 1976, Pages 672-674
The Lancet

Hypothesis
MITOCHONDRIAL CALCIUM OVERLOAD: A GENERAL MECHANISM FOR CELL-NECROSIS IN MUSCLE DISEASES

https://doi.org/10.1016/S0140-6736(76)92781-1Get rights and content

Abstract

It is suggested that the mechanism of muscle-cell necrosis in various muscle diseases is explained by an increased net influx of calcium into cells which triggers a "vicious cycle" of mitochondrial calcium overloading and energy depletion. If correct, this hypothesis may offer the basis for a more rational treatment of some muscle diseases even before their primary ætiology is known.

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