Skip to main content

Advertisement

Log in

Austrian Moderate Altitude Studies (AMAS): benefits of exposure to moderate altitudes (1,500–2,500 m)

  • Original Article
  • Published:
Sleep and Breathing Aims and scope Submit manuscript

Abstract

Objectives

A considerable part of the millions of Alpine tourists suffer from pre-existing diseases (e.g., metabolic syndrome) and high daily stress levels. The main goal of the Austrian Moderate Altitude Study (AMAS) was to investigate (a) the consequences of an active vacation at moderate altitude on the key parameters of the metabolic syndrome (AMAS I) and (b) the effects of a short active vacation on adult progenitor cells, bio-psychological parameters, and heart rate variability (HRV).

Methods

During the AMAS I pilot study (n = 22; 1,700 m a.s.l.) and AMAS I main study (n = 71; 1,700 m a.s.l. and 200 m a.s.l.), the volunteers simulated 3-week coached hiking vacations. For AMAS II, healthy volunteers (n = 13) participated in a 1-week active holiday at 1,700 m.

Results

There were significant improvements of obesity, hypertension, dyslipidemia, and insulin resistance of AMAS I patients after the vacation. In AMAS II participants, we found an increase in circulating endothelial progenitor cells as well as improvements in bio-psychological and HRV parameters.

Conclusions

Active vacations at moderate altitude are associated with a variety of positive health effects in persons with metabolic syndrome and in healthy subjects.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Inama K, Humpeler E (1981) Alpine Höhenlagen als Therapiefaktor bei Herz- Kreislauferkrankungen. In: Deetjen P, Humpeler E (eds) Medizinische Aspekte der Höhe. Georg Thieme Verlag, Stuttgart, pp 91–102

    Google Scholar 

  2. Mairbäurl H, Schobersberger W, Hasibeder W et al (1989) Exercise performance of hemodialysis patients during short-term and prolonged exposure to altitude. Clin Nephrol 32:31–39

    PubMed  Google Scholar 

  3. Reaven GM (1996) Pathophysiology of insulin resistance in human disease. Physiol Rev 75:473–486

    Google Scholar 

  4. Schobersberger W, Schmid P, Lechleitner M et al (2003) Austrian Moderate Altitude Study 2000 (AMAS 2000). The effects of moderate altitude (1,700 m) on cardiovascular and metabolic variables in patients with metabolic syndrome. Eur J Appl Physiol 88:506–514

    Article  PubMed  Google Scholar 

  5. Gunga HC, Fries D, Humpeler E et al (2003) Austrian Moderate Altitude Study (AMAS 2000)—fluid shifts, erythropoiesis, and angiogenesis in patients with metabolic syndrome at moderate altitude (1700 m). Eur J Appl Physiol 88:497–505

    Article  CAS  PubMed  Google Scholar 

  6. National Cholesterol Education Program (2001) Executive summary of the Third Report of The (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285:2486–2497

    Article  Google Scholar 

  7. World Health Organisation (1999) Definition, diagnosis, and classification of diabetes mellitus and its complications: report of a WHO consultation. Part 1: diagnosis and classification of diabetes mellitus. World Health Organisation, Geneva

    Google Scholar 

  8. Greie S, Humpeler E, Gunga HC et al (2006) Improvement of metabolic syndrome markers through altitude specific hiking vacation. J Endocrinol Invest 29:497–504

    CAS  PubMed  Google Scholar 

  9. Mair J, Hammerer-Lercher A, Mittermayr M et al (2008) 3-week hiking holidays at moderate altitude do not impair cardiac function in individuals with metabolic syndrome. Int J Cardiol 123:186–188

    Article  PubMed  Google Scholar 

  10. Frick M, Rinner A, Mair J et al (2006) Transient impairment of flow-mediated vasodilation in patients with metabolic syndrome at moderate altitude (1700 m). Int J Cardiol 109:82–87

    Article  PubMed  Google Scholar 

  11. Schobersberger W, Greie S, Humpeler E et al (2005) Austrian Moderate Altitude Study (AMAS 2000): erythropoietic activity and Hb-O2 affinity during a 3-week hiking holiday at moderate altitude in persons with metabolic syndrome. High Alt Med Biol 6:167–177

    Article  CAS  PubMed  Google Scholar 

  12. Strauss-Blasche G, Riedmann B, Schobersberger W et al (2004) Vacation at moderate and low altitude improves perceived health in individuals with metabolic syndrome. J Travel Med 11:300–304

    PubMed  Google Scholar 

  13. St-Onge M, Mignault D, Allison DB et al (2007) Evaluation of a portable device to measure daily energy expenditures in free-living adults. Am J Clin Nutr 85:742–749

    CAS  PubMed  Google Scholar 

  14. Umemura T, Higashi Y (2008) Endothelial progenitor cells: therapeutic target for cardiovascular diseases. J Pharmacol Sci 108:1–6

    Article  CAS  PubMed  Google Scholar 

  15. Brunner S, Engelmann MG, Franz WM (2008) Stem cell mobilisation for myocardial repair. Expert Opin Biol Ther 8:1675–1690

    Article  CAS  PubMed  Google Scholar 

  16. Adams V, Lenk K, Linke A et al (2004) Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia. Thromb Vasc Biol 24:684–690

    Article  CAS  Google Scholar 

  17. Steiner S, Niessner A, Ziegler S et al (2005) Endurance training increases the number of endothelial progenitor cells in patients with cardiovascular risk and coronary artery disease. Atherosclerosis 181:305–310

    Article  CAS  PubMed  Google Scholar 

  18. Theiss HD, Adam M, Greie S et al (2008) Increased levels of circulating progenitor cells after 1-week sojourn at moderate altitude (Austrian Moderate Altitude Study II, AMAS II). Resp Physiol Neurobiol 160:232–238

    Article  CAS  Google Scholar 

  19. Bech P (2004) Measuring the dimensions of psychological general well-being by the WHO-5. QoL Newsletter 32:15–16

    Google Scholar 

  20. Kallus KW (2005) Erholungs-Belastungs-Fragebogen. Swets & Zeitlinger, Lisse

    Google Scholar 

  21. Eckberg DL (1997) Sympathovagal balance: a critical appraisal. Circulation 96:3224–3232

    CAS  PubMed  Google Scholar 

  22. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology (1996) Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Eur Heart J 17:354–381

    Google Scholar 

  23. Lombardi F (2002) Clinical implications of present physiological understanding of HRV components. Card Electrophysiol Rev 6:245–249

    Article  PubMed  Google Scholar 

  24. Mück-Weymannn M, Moesler T, Joraschky P et al (2002) Depression modulates autonomic cardiac control: a physiopsychological pathway linking depression and mortality? Germ J Psych 5:67–69

    Google Scholar 

  25. Porges SW (1995) Cardiac vagal tone: a physiological index of stress. Neurosci Biobehav Rev 19:225–233

    Article  CAS  PubMed  Google Scholar 

  26. Alberti KGMM, Zimmet P, Shwa J, IDF Epidemiology Task Force Consensus Group (2005) The metabolic syndrome – a new worldwide definition. Lancet 366:1059–1062

    Article  PubMed  Google Scholar 

  27. Räikkönen K, Keltikangas-Järvinen L, Hautanen A et al (1997) Neuroendocrine mechanisms in chronic perceived stress: associations with the metabolic syndrome. Endocrinol Metab 4:247–254

    Google Scholar 

  28. Gump BB, Matthews KA (2000) Are vacations good for your health? The 9-year mortality experience after the multiple risk factor intervention trial. Psychosom Med 62:608–61

    CAS  PubMed  Google Scholar 

  29. Kop WJ, Vingerhoets AD, Kruithof GJ et al (2003) Risk factors for myocardial infarction during vacation travel. Psychosom Med 65:396–401

    Article  PubMed  Google Scholar 

  30. Caroll S, Dudfield M (2004) What is the relationship between exercise and metabolic abnormalities? A review of the metabolic syndrome. Sports Med 34:371–418

    Article  Google Scholar 

  31. Henkel V, Mergl R, Kohnen R et al (2003) Identifying depression in primary care: a comparison of different methods. Br Med J 226:200–201

    Article  Google Scholar 

  32. Hottenrott K, Hoos O, Esperer HD (2006) Heart rate variability and physical exercise. Current status. Herz 31:544–552

    Article  PubMed  Google Scholar 

  33. Nolan RP, Jong P, Barry-Bianchi SM et al (2008) Effects of drug, biobehavioral and exercise therapies on heart rate variability in coronary artery disease: a systematic review. Eur J Cardiovasc Prev Rehabil 15:386–396

    Article  PubMed  Google Scholar 

  34. Perini R, Milesi S, Biancardi L, Veicsteinas A (1996) Effects of high altitude acclimatization on heart rate variability in resting humans. Eur J Appl Physiol Occup Physiol 73:521–528

    Article  CAS  PubMed  Google Scholar 

  35. Eckberg DL (2003) The human respiratory gate. J Physiol 548:339–352

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Wolfgang Schobersberger.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schobersberger, W., Leichtfried, V., Mueck-Weymann, M. et al. Austrian Moderate Altitude Studies (AMAS): benefits of exposure to moderate altitudes (1,500–2,500 m). Sleep Breath 14, 201–207 (2010). https://doi.org/10.1007/s11325-009-0286-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11325-009-0286-y

Keywords

Navigation