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On the correlation between T2 and tissue diffusion coefficients in exercised muscle: quantitative measurements at 3T within the tibialis anterior

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Abstract

Purpose

To assess the transverse relaxation time T2 and diffusion coefficient D before and following exercise in the tibialis anterior muscle and determine whether T2 and D values were correlated.

Methods

Measurements of T2 and D were performed at 3 T within axial slices through the calf muscles of six healthy volunteers at 95 s intervals before and for 10–12 min after a dorsiflexion exercise to exhaustion.

Results

The mean ± standard deviation (SD) of T2 and D before exercise were 32 ± 1.55 ms and 1.52  ±  0.15 μm2/ms, and after exercise were 43 ± 2.5 ms and 1.72  ±  0.13 μm2/ms, respectively. The mean ± SD inter-individual recovery times of the % change in T2 and D after exercise were 7.9  ±  4.2 and 10.9 ± 7.0 min, respectively. The T2 and D values showed a significant correlation throughout the experiments (r 2  =  0.45).

Conclusions

The increase in T2 of skeletal muscle after exercise is correlated with the increase of the diffusion coefficient D and the recovery times appear similar, indicating that any model used to explain T2 increases with exercise must also account for increased diffusion coefficients.

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Authors and Affiliations

  1. Department of Physics, Yarmouk University, Irbid, Jordan

    Zaid Q. Ababneh & Anas M. Ababneh

  2. Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Riad Ababneh, Stephan E. Maier, Carl S. Winalski, Koichi Oshio & Robert V. Mulkern

  3. Department of Radiology, Children’s Hospital, Harvard Medical School, Boston, MA, USA

    Robert V. Mulkern

Authors
  1. Zaid Q. Ababneh
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  2. Riad Ababneh
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  3. Stephan E. Maier
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  4. Carl S. Winalski
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  6. Anas M. Ababneh
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  7. Robert V. Mulkern
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Correspondence to Zaid Q. Ababneh.

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Ababneh, Z.Q., Ababneh, R., Maier, S.E. et al. On the correlation between T2 and tissue diffusion coefficients in exercised muscle: quantitative measurements at 3T within the tibialis anterior. Magn Reson Mater Phy 21, 273–278 (2008). https://doi.org/10.1007/s10334-008-0120-8

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  • DOI: https://doi.org/10.1007/s10334-008-0120-8

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