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Acute altitude exposure and altered acid-base states

II. Effects on exercise performance and muscle and blood lactate

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Summary

This study examined the influence of the respiratory alkalosis of acute altitude (AL) exposure alone or in combination with metabolic acid-base manipulations on exercise performance and muscle and blood lactate accumulation. Four subjects exercised for 10 min at 50% and 75% and to exhaustion at 90% of ground level (GL) \(\dot V_{{\text{O}}_{{\text{2 max}}} } \), and at the same relative exercise intensities during three exposures to a simulated altitude of 4200 m; (i) normal (NAL), (ii) following 0.2 g·kg−1 ingestion of sodium bicarbonate (BAL), and (iii) following 0.5 g·day−1 ingestion of acetazolamide for 2 days prior to exposure (AAL). Muscle and blood lactate values were similar throughout exercise for GL and NAL. Although muscle lactates were similar among AL conditions blood lactate was reduced for AAL and increased following exhaustive exercise for BAL compared with NAL. Time to exhaustion at 90% \(\dot V_{{\text{O}}_{{\text{2 max}}} } \) was increased for NAL (10.4±1.6 min) compared with GL (7.1±0.2 min). Performance time was decreased for AAL (6.3±2.8 min) compared with NAL and BAL (12.4±4.2 min). These data suggest that the induced respiratory alkalosis of acute AL exposure may enhance exercise performance at high relative intensities. In contrast, the ingestion of acetazolamide before AL exposure would have detrimental effects on performance. The mechanism responsible for these changes may relate to the possible influence of altered extracellular acid-base states on intracellular hydrogen ion accumulation and lactate release.

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References

  • Burnell JM (1968) In vivo response of muscle to changes in CO2 tension or extracellular bicarbonate. Am J Physiol 215:1376–1383

    Google Scholar 

  • Clancy LJ, Critchley JAJH, Leitch AG, Kirby BJ, Ungar A, Flenley DC (1975) Arterial catecholamines in hypoxic exercise in man. Clin Sci 49:503–506

    Google Scholar 

  • Donovan CM, Brooks GA (1983) Endurance training affects lactate clearance, not lactate production. Am J Physiol 244:E83-E92

    Google Scholar 

  • Eldridge FL, T'SO L, Chang H (1974) Relationship between turnover rate and blood concentration of lactate in normal dogs. J Appl Physiol 37:316–320

    Google Scholar 

  • Evans WO, Robinson SM, Horstman DH, Jackson RE, Weiskoph RB (1976) Amelioration of the symptoms of acute mountain sickness by staging and acetazolamide. Aviat Space Environ Med 47:512–516

    Google Scholar 

  • Gabel RA, Weiskoph RB (1975) Ventilatory interaction between hypoxia and [H+] at chemoreceptors of man. J Appl Physiol 39:292–296

    Google Scholar 

  • Gonzolez NC, Gerbrandt M, Brown EB (1976) Changes in skeletal muscle cell pH during graded changes in \(P_{{\text{CO}}_{\text{2}} } \). Respirat Physiol 26:207–212

    Google Scholar 

  • Graham TE, Barclay JK, Wilson BA (1986) Skeletal muscle lactate release and glycolytic intermediates during hypercapnia. J Appl Physiol 60:568–575

    Google Scholar 

  • Gray GW, Bryan AC, Frayser R, Houston CS, Rennie IDB (1971) Control of acute mountain sickness. Aerospace Med 42:81–84

    Google Scholar 

  • Hackett PH, Schoene RB, Winslow RM, Peters RM Jr, West JB (1985) Acetazolamide and exercise in sojourners to 6,300 meters a preliminary study. Med Sci Sports Exerc 17:593–597

    Google Scholar 

  • Hartley LH, Vogel JA, Landowne M (1973) Central, femoral, and brachial circulation during exercise in hypoxia. J Appl Physiol 34:87–90

    Google Scholar 

  • Hirche HJ, Homback V, Longohr HD, Wacker U, Busse J (1975) Lactic acid permeation rate in working gastrocnemii of dogs during metabolic alkalosis and acidosis. Pflügers Arch 356:209–222

    Google Scholar 

  • Horstman D, Weiskopf R, Jackson RE (1980) Work capacity during 3-wk sojourn at 4,300 m: effects of relative polycythemia. J Appl Physiol 49:311–318

    Google Scholar 

  • Jones NL, Sutton JR, Taylor R, Toews CJ (1977) Effect of pH on cardiorespiratory and metabolic responses to exercise. J Appl Physiol 43:959–964

    Google Scholar 

  • Knuttgen HG, Saltin B (1973) Oxygen uptake, muscle high-energy phosphates, and lactate in exercise under acute hypoxic conditions in man. Acta Physiol Scand 87:368–376

    Google Scholar 

  • Kowalchuk JM, Heigenhauser GJF, Jones NL (1984) Effect of pH on metabolic and cardiorespiratory responses during progressive exercise. J Appl Physiol 57:1558–1563

    Google Scholar 

  • Maher JT, Jones LG, Hartley H (1974) Effects of high-altitude exposure on submaximal endurance capacity of men. J Appl Physiol 37:895–898

    Google Scholar 

  • Maughan RN (1982) A simple, rapid method for the determination of glucose, lactate, pyruvate, alanine, 3-hydroxybutyrate and acetoacetate on a single 20-μl blood sample. Clin Chim Acta 122:231–240

    Google Scholar 

  • McCartney N, Heigenhauser GJF, Jones NL (1983) Effects of pH on maximal power output and fatigue during shortterm dynamic exercise. J Appl Physiol 55:225–229

    Google Scholar 

  • Nakamuru Y, Schwartz A (1972) The influence of hydrogen ion concentration on calcium binding and release by skeletal muscle sarcoplasmic reticulum. J Gen Physiol 59:22–32

    Google Scholar 

  • Oren A, Whipp BJ, Wasserman K (1982) Effect of acid-base status on the kinetics of the ventilatory response to moderate exercise. J Appl Physiol 52:1013–1017

    Google Scholar 

  • Portzehl H, Zaoralek P, Gaudin J (1969) The activation by Ca2+ of the ATPase of extracted muscle fibrils with variation of ionic strength, pH and concentration of MgATP. Biochem Biophys Acta 189:440–448

    Google Scholar 

  • Schoene RB, Bates PW, Larson EB, Pierson DJ (1983) Effect of acetazolamide on normoxic and hypoxic exercise in humans at sea level. J Appl Physiol 55:1772–1776

    Google Scholar 

  • Seo Y (1984) Effects of extracellular pH on lactate efflux from frog sartorius muscle. Am J Physiol 247:C175-C181

    Google Scholar 

  • Spriet LL, Matsos CG, Peters SJ, Heigenhauser GJF, Jones NL (1985) Effects of acidosis on rat muscle metabolism and performance during heavy exercise. Am J Physiol 248:C337-C347

    Google Scholar 

  • Stainsby WN, Sumners C, Andrew GM (1984) Plasma catecholamines and their effect on blood lactate and muscle lactate output. J Appl Physiol 57:321–325

    Google Scholar 

  • Stewart PA (1983) Modern quantitative acid-base chemistry. Can J Physiol Pharmacol 61:1444–1461

    Google Scholar 

  • Sutton JR, Jones NL, Toews CJ (1981) Effect of pH on muscle glycolysis during exercise. Clin Sci 61:331–338

    Google Scholar 

  • Tesch P (1980) Muscle fatigue in man with special reference to lactate accumulation during short term intense exercise. Acta Physiol Scand [Suppl] 480:5–31

    Google Scholar 

  • Trivedi B, Danforth WH (1966) Effect of pH on the kinetics of frog muscle phosphofructokinase. J Biol Chem 241:4110–4112

    Google Scholar 

  • Wilkes D, Gledhill N, Smyth R (1983) Effect of acute induced metabolic alkalosis on 800-m racing time. Med Sci Sports Exerc 15:277–280

    Google Scholar 

  • Young AJ, Evans WJ, Cymerman A, Pandolf KB, Knapik JJ, Maher JT (1982) Sparing effect of chronic high-altitude exposure on muscle glycogen utilization. J Appl Physiol 52:857–862

    Google Scholar 

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DCIEM report no. 81-P-56

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McLellan, T., Jacobs, I. & Lewis, W. Acute altitude exposure and altered acid-base states. Europ. J. Appl. Physiol. 57, 445–451 (1988). https://doi.org/10.1007/BF00417991

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