PT  - JOURNAL ARTICLE
AU  - June S Yang
AU  - Jeffry N Gerber
AU  - Hyun J You
TI  - Association between fasting insulin and high-sensitivity C reactive protein in Korean adults
AID  - 10.1136/bmjsem-2017-000236
DP  - 2017 Jun 01
TA  - BMJ Open Sport & Exercise Medicine
PG  - e000236
VI  - 3
IP  - 1
4099  - http://bmjopensem.bmj.com/content/3/1/e000236.short
4100  - http://bmjopensem.bmj.com/content/3/1/e000236.full
SO  - BMJ OPEN SP EX MED2017 Jun 01; 3
AB  - Background High-sensitivity C reactive protein (hs-CRP) is a reliable indicator of atherosclerotic diseases and is associated with hyperinsulinaemia. The purpose of this study is to examine the association between hs-CRP and fasting insulin levels in Korean adults not taking medication for hypertension, dyslipidaemia or diabetes, nor provided with specific dietary advice.Methods This cross-sectional study included 2588 subjects who participated in the 2015 Korean National Health and Nutrition Examination Survey. High-risk hs-CRP was defined as hs-CRP>2 mg/L. Subjects were divided into four groups with fasting insulin (<5, 5–10, 10–15,>15 uIU/mL)Results The mean hs-CRP in our sample was 1.22 mg/L. hs-CRP was positively associated with fasting insulin level. The occurrence of high-risk hs-CRP with increasing fasting insulin levels was 7.6%, 9.8%, 19.1% and 28.2%, respectively. In comparing high-risk hs-CRP between the highest (>15 µIU/mL) and lowest (<5 µIU/mL) insulin groups, the OR (95% CI) was 4.59 (2.77–7.58). triglycerides/high-density lipoprotein ratio was also associated with hs-CRP. Low-density lipoprotein cholesterol was not associated with hs-CRP.Conclusions Higher level of fasting insulin is positively associated with high-risk hs-CRP.