@article {Yange000236, author = {June S Yang and Jeffry N Gerber and Hyun J You}, title = {Association between fasting insulin and high-sensitivity C reactive protein in Korean adults}, volume = {3}, number = {1}, elocation-id = {e000236}, year = {2017}, doi = {10.1136/bmjsem-2017-000236}, publisher = {BMJ Specialist Journals}, abstract = {Background High-sensitivity C reactive protein (hs-CRP) is a reliable indicator of atherosclerotic diseases and is associated with hyperinsulinaemia. The purpose of this study is to examine the association between hs-CRP and fasting insulin levels in Korean adults not taking medication for hypertension, dyslipidaemia or diabetes, nor provided with specific dietary advice.Methods This cross-sectional study included 2588 subjects who participated in the 2015 Korean National Health and Nutrition Examination Survey. High-risk hs-CRP was defined as hs-CRP\>2 mg/L. Subjects were divided into four groups with fasting insulin (\<5, 5{\textendash}10, 10{\textendash}15,\>15 uIU/mL)Results The mean hs-CRP in our sample was 1.22 mg/L. hs-CRP was positively associated with fasting insulin level. The occurrence of high-risk hs-CRP with increasing fasting insulin levels was 7.6\%, 9.8\%, 19.1\% and 28.2\%, respectively. In comparing high-risk hs-CRP between the highest (\>15 {\textmu}IU/mL) and lowest (\<5 {\textmu}IU/mL) insulin groups, the OR (95\% CI) was 4.59 (2.77{\textendash}7.58). triglycerides/high-density lipoprotein ratio was also associated with hs-CRP. Low-density lipoprotein cholesterol was not associated with hs-CRP.Conclusions Higher level of fasting insulin is positively associated with high-risk hs-CRP.}, URL = {https://bmjopensem.bmj.com/content/3/1/e000236}, eprint = {https://bmjopensem.bmj.com/content/3/1/e000236.full.pdf}, journal = {BMJ Open Sport \& Exercise Medicine} }